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A rapid smartphone-based lactate dehydrogenase test for neonatal diagnostics at the point of care
Karolinska Inst, Dept Clin Res & Educ, Sodersjukhuset, Stockholm, Sweden.;Sachs Children & Youth Hosp, Neonatal Unit, Stockholm, Sweden..
Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden.;Karolinska Inst, Dept Publ Hlth Sci, Stockholm, Sweden.;TRAC Sweden Vietnam, Hanoi, Vietnam..
Calmark Sweden AB, Stockholm, Sweden..
Calmark Sweden AB, Stockholm, Sweden.;Uppsala Univ, Dept Med Sci Biomed Struct & Funct, Uppsala, Sweden..
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2019 (engelsk)Inngår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 9, artikkel-id 9301Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

There is a growing recognition of the importance of point-of-care tests (POCTs) for detecting critical neonatal illnesses to reduce the mortality rate in newborns, especially in low-income countries, which account for 98 percent of reported neonatal deaths. Lactate dehydrogenase (LDH) is a marker of cellular damage as a result of hypoxia-ischemia in affected organs. Here, we describe and test a POC LDH test direct from whole blood to provide early indication of serious illness in the neonate. The sample-inresult- out POC platform is specifically designed to meet the needs at resource-limited settings. Plasma is separated from whole blood on filter paper with dried-down reagents for colorimetric reaction, combined with software for analysis using a smartphone. The method was clinically tested in newborns in two different settings. In a clinical cohort of newborns of Stockholm (n = 62) and Hanoi (n = 26), the value of R using Pearson's correlation test was 0.91 (p < 0.01) and the R-2 = 0.83 between the two methods. The mean LDH (+/- SD) for the reference method vs. the POC-LDH was 551 (+/- 280) U/L and 552 (+/- 249) U/L respectively, indicating the clinical value of LDH values measured in minutes with the POC was comparable with standardized laboratory analyses.

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Nature Publishing Group, 2019. Vol. 9, artikkel-id 9301
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URN: urn:nbn:se:kth:diva-255307DOI: 10.1038/s41598-019-45606-0ISI: 000472837000025PubMedID: 31243323Scopus ID: 2-s2.0-85067938114OAI: oai:DiVA.org:kth-255307DiVA, id: diva2:1339854
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QC 20190731

Tilgjengelig fra: 2019-07-31 Laget: 2019-07-31 Sist oppdatert: 2019-07-31bibliografisk kontrollert

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