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Measuring the solubility of a quickly transforming metastable polymorph of carbamazepine
Univ Limerick, Dept Chem & Environm Sci, Mat & Surface Sci Inst, Limerick, Ireland.ORCID-id: 0000-0003-1790-2310
Vise andre og tillknytning
2013 (engelsk)Inngår i: Organic Process Research and Development, ISSN 1083-6160, Vol. 17, nr 3, s. 512-518Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The solubility of the stable FIII polymorph of the pharmaceutical compound carbamazepine was measured by determining its solubility gravimetrically in ethanol and methanol. Where the metastable FI polymorph was suspended in a solution of ethanol, the stable FIII polymorph nucleated immediately, initiating a solution-mediated transformation from FI to FIII. This meant that the FI polymorph was not in thermodynamic equilibrium with the solution as FI was continually dissolving while FIII was growing. We show that the solubility of FI can be accurately measured by in situ microscopy using an adaption of the bracketing method, and the results show that the solubility is close to but higher than the maximum solution concentration reached during the solution mediated transformation from FI to FIII carbamazepine in both solvents. The technique demonstrates a relatively simple and robust method for determining the solubility of a metastable crystalline phase which transforms quickly in solution.

sted, utgiver, år, opplag, sider
American Chemical Society (ACS), 2013. Vol. 17, nr 3, s. 512-518
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URN: urn:nbn:se:kth:diva-260458DOI: 10.1021/op300228gISI: 000316375600027Scopus ID: 2-s2.0-84875175871OAI: oai:DiVA.org:kth-260458DiVA, id: diva2:1355693
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QC 20190930

Tilgjengelig fra: 2019-09-30 Laget: 2019-09-30 Sist oppdatert: 2019-11-12bibliografisk kontrollert

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Rasmuson, Åke C.

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