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Speeding Up Percolator
Univ Calif Davis, Dept Publ Hlth Sci, Davis, CA 95616 USA..
Swiss Fed Inst Technol, Dept Comp Sci, CH-8092 Zurich, Switzerland..
Swiss Fed Inst Technol, Dept Comp Sci, CH-8092 Zurich, Switzerland..
Swiss Fed Inst Technol, Dept Comp Sci, CH-8092 Zurich, Switzerland..
Vise andre og tillknytning
2019 (engelsk)Inngår i: Journal of Proteome Research, ISSN 1535-3893, E-ISSN 1535-3907, Vol. 18, nr 9, s. 3353-3359Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The processing of peptide tandem mass spectrometry data involves matching observed spectra against a sequence database. The ranking and calibration of these peptide-spectrum matches can be improved substantially using a machine learning postprocessor. Here, we describe our efforts to speed up one widely used postprocessor, Percolator. The improved software is dramatically faster than the previous version of Percolator, even when using relatively few processors. We tested the new version of Percolator on a data set containing over 215 million spectra and recorded an overall reduction to 23% of the running time as compared to the unoptimized code. We also show that the memory footprint required by these speedups is modest relative to that of the original version of Percolator.

sted, utgiver, år, opplag, sider
AMER CHEMICAL SOC , 2019. Vol. 18, nr 9, s. 3353-3359
Emneord [en]
tandem mass spectrometry, machine learning, support vector machine, SVM, percolator
HSV kategori
Identifikatorer
URN: urn:nbn:se:kth:diva-261034DOI: 10.1021/acs.jproteome.9b00288ISI: 000485089100012PubMedID: 31407580Scopus ID: 2-s2.0-85071999233OAI: oai:DiVA.org:kth-261034DiVA, id: diva2:1356730
Merknad

QC 20191002

Tilgjengelig fra: 2019-10-02 Laget: 2019-10-02 Sist oppdatert: 2019-10-02bibliografisk kontrollert

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