Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Mannose-binding lectin does not explain the dismal prognosis after an acute coronary event in dysglycaemic patients: A report from the GAMI cohort
Karolinska Inst, Dept Med Solna, Solnavagen 1, S-17176 Stockholm, Sweden..
Karolinska Inst, Dept Med Solna, Solnavagen 1, S-17176 Stockholm, Sweden..
Aarhus Univ, Dept Clin Med, Med Steno Aarhus Res Lab, Aarhus, Denmark..
Aarhus Univ Hosp, Steno Diabet Ctr Aarhus, Aarhus, Denmark..
Vise andre og tillknytning
2022 (engelsk)Inngår i: Cardiovascular Diabetology, E-ISSN 1475-2840, Vol. 21, nr 1, artikkel-id 129Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background Mannose binding lectin (MBL) has been suggested to be associated with an impaired cardiovascular prognosis in dysglycaemic conditions, but results are still contrasting. Our aims are (i) to examine whether MBL levels differ between patients with an acute myocardial infarction (MI) and healthy controls and between subgroups with different glucose tolerance status, and (ii) to investigate the relation between MBL and future cardiovascular events. Methods MBL levels were assessed at discharge and after 3 months in 161 AMI patients without any previously known glucose perturbations and in 183 age- and gender-matched controls from the Glucose metabolism in patients with Acute Myocardial Infarction (GAMI) study. Participants were classified as having dysglycaemia, i.e. type 2 diabetes or impaired glucose tolerance, or not by an oral glucose tolerance test. The primary outcome was a composite of cardiovascular events comprising cardiovascular death, AMI, stroke or severe heart failure during 11 years of follow-up. Total and cardiovascular mortality served as secondary outcomes. Results At hospital discharge patients had higher MBL levels (median 1246 mu g/L) than three months later (median 575 mu g/L; p < 0.01), the latter did not significantly differ from those in the controls (801 mu g/L; p = 0.47). MBL levels were not affected by dysglycaemia either in patients or controls. Independent of glycaemic state, increasing MBL levels did not predict any of the studied outcomes in patients. In unadjusted analyses increasing MBL levels predicted cardiovascular events (hazard ratio HR: 1.67, 95% confidence interval CI 1.06-2.64) and total mortality (HR 1.53, 95% CI 1.12-2.10) in the control group. However, this did not remain in adjusted analyses. Conclusions Patients had higher MBL levels than controls during the hospital phase of AMI, supporting the assumption that elevated MBL reflects acute stress. MBL was not found to be independently associated with cardiovascular prognosis in patients with AMI regardless of glucose state.

sted, utgiver, år, opplag, sider
Springer Nature , 2022. Vol. 21, nr 1, artikkel-id 129
Emneord [en]
Dysglycaemia, Cardiovascular disease, Inflammation, Complement system proteins, Mannose binding lectin, Biomarker, Prognosis
HSV kategori
Identifikatorer
URN: urn:nbn:se:kth:diva-315841DOI: 10.1186/s12933-022-01562-0ISI: 000822341600001PubMedID: 35804351Scopus ID: 2-s2.0-85133662189OAI: oai:DiVA.org:kth-315841DiVA, id: diva2:1684126
Merknad

QC 20220721

Tilgjengelig fra: 2022-07-21 Laget: 2022-07-21 Sist oppdatert: 2024-07-04bibliografisk kontrollert

Open Access i DiVA

Fulltekst mangler i DiVA

Andre lenker

Forlagets fulltekstPubMedScopus

Person

Näsman, Per

Søk i DiVA

Av forfatter/redaktør
Näsman, Per
Av organisasjonen
I samme tidsskrift
Cardiovascular Diabetology

Søk utenfor DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 22 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf