Motivated by the interest in steam explosion in chemical solutions and seawater, a series of tests were carried out in the MISTEE facility at KTH to investigate steam explosion characteristics as multiple molten droplets of tin were falling through a coolant pool containing deionized water, boric acid solution, neutral solution of boric acid and sodium phosphate, and seawater, separately. The experimental results revealed distinct and complex characteristics of steam explosion of multiple droplets, which were not observed in previous single-droplet steam explosion experiments. The tin melt samples of 5 g and 20 g were employed to formulate different numbers of multiple droplets. In the test with 5 g melt, steam explosion was more energetic at a deeper explosion location − a similar trend found in the single-droplet steam explosion test with 1 g melt. However, the test of 20 g melt did not show a clear trend in a wide range of explosion depth. The peak pressure and impulse increased with increasing mass of melt sample. The steam explosion occurred more closely to the coolant pool surfaces in the seawater and chemical solutions than in deionized water. Steam explosion intensity was significantly reduced in a neutral solution containing 1.2 wt.% boric acid and sodium phosphate. The influence of the chemical solutions on steam explosion was diminishing in the tests with multiple droplets.