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Mechanism of graded persistent cellular activity of entorhinal cortex layer V neurons
KTH, Skolan för datavetenskap och kommunikation (CSC), Beräkningsbiologi, CB.ORCID-id: 0000-0003-0281-9450
Vise andre og tillknytning
2006 (engelsk)Inngår i: Neuron, ISSN 0896-6273, E-ISSN 1097-4199, Vol. 49, nr 5, s. 735-746Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Working memory is an emergent property of neuronal networks, but its cellular basis remains elusive. Recent data show that principal neurons of the entorhinal cortex display persistent firing at graded firing rates that can be shifted up or down in response to brief excitatory or inhibitory stimuli. Here, we present a model of a potential mechanism for graded firing. Our multicompartmental model provides stable plateau firing generated by a nonspecific calcium-sensitive cationic (CAN) current. Sustained firing is insensitive to small variations in Ca2+ concentration in a neutral zone. However, both high and low Ca2+ levels alter firing rates. Specifically, increases in persistent firing rate are triggered only during high levels of calcium, while decreases in rate occur in the presence of low levels of calcium. The model is consistent with detailed experimental observations and provides a mechanism for maintenance of memory-related activity in individual neurons.

sted, utgiver, år, opplag, sider
2006. Vol. 49, nr 5, s. 735-746
Emneord [en]
parametric working-memory, head-direction cells, prefrontal cortex, recurrent network, spatial navigation, neural integrator, cation current, model neuron, eye position, ii neurons
HSV kategori
Identifikatorer
URN: urn:nbn:se:kth:diva-15525DOI: 10.1016/j.neuron.2006.01.036ISI: 000236070600014Scopus ID: 2-s2.0-33344467487OAI: oai:DiVA.org:kth-15525DiVA, id: diva2:333566
Merknad
QC 20100525 QC 20111215Tilgjengelig fra: 2010-08-05 Laget: 2010-08-05 Sist oppdatert: 2018-01-12bibliografisk kontrollert

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