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Neurotransmitter phenotype-specific expression changes in developing sympathetic neurons
Vise andre og tillknytning
2007 (engelsk)Inngår i: Molecular and Cellular Neuroscience, ISSN 1044-7431, E-ISSN 1095-9327, Vol. 35, nr 3, s. 397-408Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

During late developmental phases individual sympathetic neurons undergo a switch from noradrenergic to cholinergic neurotransmission. This phenomenon of plasticity depends on target-derived signals in vivo and is triggered by neurotrophic factors in neuronal cultures. To analyze genome-wide expression differences between the two transmitter phenotypes we employed DNA microarrays. RNA expression profiles were obtained from chick paravertebral sympathetic ganglia, treated with neurotrophin 3, glial cell line-derived neurotrophic factor or ciliary neurotrophic factor, all of which stimulate cholinergic differentiation. Results were compared with the effect of nerve growth factor, which functions as a pro-noradrenergic stimulus. The gene set common to all three comparisons defined the noradrenergic and cholinergic synexpression groups. Several functional categories, such as signal transduction, G-protein-coupled signaling, cation transport, neurogenesis and synaptic transmission, were enriched in these groups. Experiments based on the prediction that some of the identified genes play a role in the neurotransmitter switch identified bone morphogenetic protein signaling as an inhibitor of cholinergic differentiation.

sted, utgiver, år, opplag, sider
2007. Vol. 35, nr 3, s. 397-408
Emneord [en]
acetylcholine, noradrenalin, sympathetic, neurotrophic, Microarray, nerve growth-factor, cholinergic differentiation, neural crest, in-vivo, ganglia, system, induction, cytokines, pathways, signals
Identifikatorer
URN: urn:nbn:se:kth:diva-16793DOI: 10.1016/j.mcn.2007.03.014ISI: 000248057600001Scopus ID: 2-s2.0-34250799884OAI: oai:DiVA.org:kth-16793DiVA, id: diva2:334836
Merknad
QC 20100525Tilgjengelig fra: 2010-08-05 Laget: 2010-08-05 Sist oppdatert: 2017-12-12bibliografisk kontrollert

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