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Controlled ring-opening polymerization of lactones and lactides
KTH, Tidigare Institutioner                               , Polymerteknologi.ORCID-id: 0000-0001-8696-9143
KTH, Tidigare Institutioner                               , Polymerteknologi.ORCID-id: 0000-0002-1631-1781
2000 (engelsk)Inngår i: Macromolecular Symposia, ISSN 1022-1360, E-ISSN 1521-3900, Vol. 157, s. 39-46Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

1,5-dioxepan-2-one (DXO) is presented as a versatile component in biodegradable polymers for biomedical applications. Copolymerization of DXO and L-lactide yielded a semi-crystalline, yet flexible, material where the extent of crystallinity and erosion characteristics were controlled by an appropriate choice of copolymer composition. Crosslinked PDXO was polymerized as a novel biodegradable elastomer. The degradation behavior of these materials were explored in vitro. Microspheres from poly(DXO-co-L-LA) were prepared and shown to be promising candidates for controlled release. The polymer composition and drug solubility provided effective means of controlling the drug delivery pattern.

sted, utgiver, år, opplag, sider
2000. Vol. 157, s. 39-46
Emneord [en]
polymers
Identifikatorer
URN: urn:nbn:se:kth:diva-20066ISI: 000089632200006OAI: oai:DiVA.org:kth-20066DiVA, id: diva2:338759
Merknad
QC 20100525Tilgjengelig fra: 2010-08-10 Laget: 2010-08-10 Sist oppdatert: 2020-01-08bibliografisk kontrollert

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