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Theoretical Comparison of the Iodine Quantification Accuracy of Two Spectral CT Technologies
KTH, Skolan för teknikvetenskap (SCI), Fysik, Medicinsk bildfysik.
KTH, Skolan för teknikvetenskap (SCI), Fysik, Medicinsk bildfysik.ORCID-id: 0000-0002-5092-8822
2014 (engelsk)Inngår i: IEEE Transactions on Medical Imaging, ISSN 0278-0062, E-ISSN 1558-254X, Vol. 33, nr 2, s. 556-565Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

We compare the theoretical limits of iodine quantification for the photon counting multibin and dual energy technologies. Dual energy systems by necessity have to make prior assumptions in order to quantify iodine. We explicitly allow the multibin system to make the same assumptions and also allow them to be wrong. We isolate the effect of technology from imperfections and implementation issues by assuming both technologies to be ideal, i.e., without scattered radiation, unity detection efficiency and perfect energy response functions, and by applying the Cramer-Rao lower bound methodology to assess the quantification accuracy. When priors are wrong the maximum likelihood estimates will be biased and the mean square error of the quantification error is a more appropriate figure of merit. The evaluation assumes identical X-ray spectra for both methodologies and for that reason a sensitivity analysis is performed with regard to the assumed X-ray spectrum. We show that when iodine is quantified over regions of interest larger than 6 cm, multibin systems benefit by independent estimation of three basis functions. For smaller regions of interest multibin systems can increase quantification accuracy by making the same prior assumptions as dual energy systems.

sted, utgiver, år, opplag, sider
2014. Vol. 33, nr 2, s. 556-565
Emneord [en]
Dual energy computed tomography (CT), iodine quantification, photon counting multibin CT, spectral CT
HSV kategori
Identifikatorer
URN: urn:nbn:se:kth:diva-143448DOI: 10.1109/TMI.2013.2290198ISI: 000331298000027Scopus ID: 2-s2.0-84894053605OAI: oai:DiVA.org:kth-143448DiVA, id: diva2:707475
Merknad

QC 20140324

Tilgjengelig fra: 2014-03-24 Laget: 2014-03-21 Sist oppdatert: 2017-12-05bibliografisk kontrollert

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Persson, Mats

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