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Hyperoxia affects the regional pulmonary ventilation/perfusion ratio: an electrical impedance tomography study
Vise andre og tillknytning
2014 (engelsk)Inngår i: Acta Anaesthesiologica Scandinavica, ISSN 0001-5172, E-ISSN 1399-6576, Vol. 58, nr 6, s. 716-725Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background The way in which hyperoxia affects pulmonary ventilation and perfusion is not fully understood. We investigated how an increase in oxygen partial pressure in healthy young volunteers affects pulmonary ventilation and perfusion measured by thoracic electrical impedance tomography (EIT). Methods Twelve semi-supine healthy male volunteers aged 21-36 years were studied while breathing room air and air-oxygen mixtures (FiO2) that resulted in predetermined transcutaneous oxygen partial pressures (tcPO2) of 20, 40 and 60kPa. The magnitude of ventilation (Zv) and perfusion (ZQ)-related changes in cyclic impedance variations, were determined using an EIT prototype equipped with 32 electrodes around the thorax. Regional changes in ventral and dorsal right lung ventilation (V) and perfusion (Q) were estimated, and V/Q ratios calculated. Results There were no significant changes in Zv with increasing tcPO2 levels. ZQ in the dorsal lung increased with increasing tcPO2 (P=0.01), whereas no such change was seen in the ventral lung. There was a simultaneous decrease in V/Q ratio in the dorsal region during hyperoxia (P=0.04). Two subjects did not reach a tcPO2 of 60kPa despite breathing 100% oxygen. Conclusion These results indicate that breathing increased concentrations of oxygen induces pulmonary vasodilatation in the dorsal lung even at small increases in FiO2. Ventilation remains unchanged. Local mismatch of ventilation and perfusion occurs in young healthy men, and the change in ventilation/perfusion ratio can be determined non-invasively by EIT.

sted, utgiver, år, opplag, sider
2014. Vol. 58, nr 6, s. 716-725
Emneord [en]
Cerebral-Blood-Flow, Lung Perfusion, Ventilatory Response, Supplemental Oxygen, Healthy-Volunteers, Stimulus-Response, Piglet Model, Circulation, Collapse, Hypoxia
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Identifikatorer
URN: urn:nbn:se:kth:diva-148363DOI: 10.1111/aas.12323ISI: 000337967300011Scopus ID: 2-s2.0-84903183090OAI: oai:DiVA.org:kth-148363DiVA, id: diva2:736427
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QC 20140806

Tilgjengelig fra: 2014-08-06 Laget: 2014-08-05 Sist oppdatert: 2017-12-05bibliografisk kontrollert

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