Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Existence and control of Go/No-Go decision transition threshold in the striatum
KTH, Skolan för datavetenskap och kommunikation (CSC), Beräkningsbiologi, CB. University of Freiburg, Germany.
University of Freiburg, Germany.
KTH, Skolan för datavetenskap och kommunikation (CSC), Beräkningsbiologi, CB. University of Freiburg, Germany.ORCID-id: 0000-0002-8044-9195
2015 (engelsk)Inngår i: PloS Computational Biology, ISSN 1553-734X, E-ISSN 1553-7358, Vol. 11, nr 4, artikkel-id e1004233Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

A typical Go/No-Go decision is suggested to be implemented in the brain via the activation of the direct or indirect pathway in the basal ganglia. Medium spiny neurons (MSNs) in the striatum, receiving input from cortex and projecting to the direct and indirect pathways express D1 and D2 type dopamine receptors, respectively. Recently, it has become clear that the two types of MSNs markedly differ in their mutual and recurrent connectivities as well as feedforward inhibition from FSIs. Therefore, to understand striatal function in action selection, it is of key importance to identify the role of the distinct connectivities within and between the two types of MSNs on the balance of their activity. Here, we used both a reduced firing rate model and numerical simulations of a spiking network model of the striatum to analyze the dynamic balance of spiking activities in D1 and D2 MSNs. We show that the asymmetric connectivity of the two types of MSNs renders the striatum into a threshold device, indicating the state of cortical input rates and correlations by the relative activity rates of D1 and D2 MSNs. Next, we describe how this striatal threshold can be effectively modulated by the activity of fast spiking interneurons, by the dopamine level, and by the activity of the GPe via pallidostriatal backprojections. We show that multiple mechanisms exist in the basal ganglia for biasing striatal output in favour of either the `Go' or the `No-Go' pathway. This new understanding of striatal network dynamics provides novel insights into the putative role of the striatum in various behavioral deficits in patients with Parkinson's disease, including increased reaction times, L-Dopa-induced dyskinesia, and deep brain stimulation-induced impulsivity.

sted, utgiver, år, opplag, sider
PLOS , 2015. Vol. 11, nr 4, artikkel-id e1004233
Emneord [en]
Striatum, Basal ganglia, correlations, decision-making, Parkinson's disease, dopamine
HSV kategori
Identifikatorer
URN: urn:nbn:se:kth:diva-165968DOI: 10.1371/journal.pcbi.1004233ISI: 000354517600062PubMedID: 25910230Scopus ID: 2-s2.0-84929485226OAI: oai:DiVA.org:kth-165968DiVA, id: diva2:809217
Merknad

QC 20150511

Tilgjengelig fra: 2015-04-30 Laget: 2015-04-30 Sist oppdatert: 2018-01-11bibliografisk kontrollert

Open Access i DiVA

fulltext(2205 kB)104 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 2205 kBChecksum SHA-512
4b060708637ffc69b10e07d836b0eb846fb01291fcf35647007dedbe9f1e96206291db979b935d360a367ac6bf472dbab0bd509b2cee1f7ab28c76671ec26e23
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekstPubMedScopusPublihser's website

Personposter BETA

Kumar, Arvind

Søk i DiVA

Av forfatter/redaktør
Bahuguna, JyotikaKumar, Arvind
Av organisasjonen
I samme tidsskrift
PloS Computational Biology

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 104 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 468 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf