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Reciprocal voltage sensor-to-pore coupling leads to potassium channel C-type inactivation
KTH, Skolan för teknikvetenskap (SCI), Teoretisk fysik, Beräkningsbiofysik.
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2016 (engelsk)Inngår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 6, artikkel-id 27562Artikkel i tidsskrift (Fagfellevurdert) Published
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Abstract [en]

Voltage-gated potassium channels open at depolarized membrane voltages. A prolonged depolarization causes a rearrangement of the selectivity filter which terminates the conduction of ions - a process called slow or C-type inactivation. How structural rearrangements in the voltage-sensor domain (VSD) cause alteration in the selectivity filter, and vice versa, are not fully understood. We show that pulling the pore domain of the Shaker potassium channel towards the VSD by a Cd2+ bridge accelerates C-type inactivation. Molecular dynamics simulations show that such pulling widens the selectivity filter and disrupts the K+ coordination, a hallmark for C-type inactivation. An engineered Cd2+ bridge within the VSD also affect C-type inactivation. Conversely, a pore domain mutation affects VSD gating-charge movement. Finally, C-type inactivation is caused by the concerted action of distant amino acid residues in the pore domain. All together, these data suggest a reciprocal communication between the pore domain and the VSD in the extracellular portion of the channel.

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Nature Publishing Group, 2016. Vol. 6, artikkel-id 27562
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URN: urn:nbn:se:kth:diva-189368DOI: 10.1038/srep27562ISI: 000377343800001PubMedID: 27278891Scopus ID: 2-s2.0-84974559964OAI: oai:DiVA.org:kth-189368DiVA, id: diva2:947067
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QC 20160706

Tilgjengelig fra: 2016-07-06 Laget: 2016-07-04 Sist oppdatert: 2017-11-28bibliografisk kontrollert

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