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The Impact of Aortic Arch Geometry on Flow Characteristics
KTH, Skolan för teknikvetenskap (SCI), Mekanik, Biomekanik. KTH, Skolan för teknikvetenskap (SCI), Centra, Linné Flow Center, FLOW.ORCID-id: 0000-0001-9976-8316
KTH, Skolan för teknikvetenskap (SCI), Mekanik, Biomekanik. KTH, Skolan för teknikvetenskap (SCI), Centra, Linné Flow Center, FLOW.
KTH, Skolan för teknikvetenskap (SCI), Mekanik. KTH, Skolan för teknikvetenskap (SCI), Centra, Linné Flow Center, FLOW.ORCID-id: 0000-0001-7330-6965
KTH, Skolan för teknikvetenskap (SCI), Mekanik. KTH, Skolan för teknikvetenskap (SCI), Centra, Linné Flow Center, FLOW.
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2013 (Engelska)Ingår i: / [ed] AIAA, AIAA, 2013Konferensbidrag, Publicerat paper (Refereegranskat)
Abstract [en]

Cardiovascular defects characterized by geometrical anomalies of the aorta and its eecton the blood ow is the focus of this study. Not only are the local ow characteristicsgeometry dependent, but they are also directly connected to the rheological properties ofblood. Flow characteristics such as wall shear stress are often postulated to play a centralrole in the development of vascular disease.In this study, blood is considered to be a non-Newtonian uid and modeled via theQuemada model, an empirical model that is valid for dierent red blood cell loading.Three patient-specic geometries of the aortic arch are investigated numerically. Thethree geometries investigated in this study all display malformations that are prevalent inpatients having the genetic disorder Turner syndrome. The results show a highly complexow with regions of secondary ow that are enhanced in two of the three aortas. Moreover,blood ow is clearly diverted due to the malformations, moving to a larger extent throughthe branches of the arch instead of through the descending aorta. The geometry havingan elongated transverse aorta is found to be subjected to larger areas of highly oscillatorylow wall shear stress.

Ort, förlag, år, upplaga, sidor
AIAA, 2013.
Nyckelord [en]
LES, aortic flow, healthy and disease
Nationell ämneskategori
Strömningsmekanik och akustik
Identifikatorer
URN: urn:nbn:se:kth:diva-124163DOI: 10.2514/6.2013-1110Scopus ID: 2-s2.0-84881459212OAI: oai:DiVA.org:kth-124163DiVA, id: diva2:633266
Konferens
51st AIAA Aerospace Sciences Meeting
Anmärkning

QC 20131206

Tillgänglig från: 2013-06-26 Skapad: 2013-06-26 Senast uppdaterad: 2013-12-06Bibliografiskt granskad
Ingår i avhandling
1. Blood Flow variations in Large Arteries due to non-Newtonian rheology
Öppna denna publikation i ny flik eller fönster >>Blood Flow variations in Large Arteries due to non-Newtonian rheology
2013 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

The blood is a complex fluid that contains, in addition to water, cells, macro-molecules and a large number of smaller molecules. The physical properties of the blood are therefore the result of non-linear interactions of its constituents, which are influenced by the local flow field conditions. Hence, the local blood viscosity is a function of the local concentration of the blood constituents and the local flow field itself. This study considers the flow of blood-like fluids in generalised 90-degree bifurcating pipes and patient-specific arterial bifurcations relevant to the large aortic branches in humans. It is shown that the Red Blood Cell (RBC) distribution in the region of bifurcations may lead to large changes in the viscosity, with implications on the concentrations of the various cells in the blood plasma. This in turn implies that the flow in the near wall regions is more difficult to estimate and predict than that under the assumption of a homogeneous fluid. The rheological properties of blood are complex and are difficult to measure, since the results depend on the measuring equipment and the inherent flow conditions. We attempt to model the viscosity of water containing different volume fractions of non-deforming RBC-like particles in tubes. The apparent viscosities of the mixtures obtained from these model experiments have been compared to the predictions of the different rheological models found in the literature. The same rheological models have also been used in the different simulations, where the local RBC concentration and local shear rate are used in the viscosity models. The flow simulations account for the non-linearity due to coupling between the flow and fluid rheology. Furthermore, from a physiological perspective, it is shown that oscillatory wall shear stresses are affected by changes in RBC concentration in the regions of the bifurcation associated with atherogenesis. The intrinsic shear thinning rheological property of the blood, in conjunction with stagnation in separated flows, may be responsible for elevated temporal wall shear stress gradients (TWSSG) influencing endothelial cell behaviour, which has been postulated to play a role in the development of atherosclerosis. The blood-like fluid properties along with variations in the RBC concentration could also lead to variations in the developing flow structures in the larger arteries that could influence the work the heart has to bear.

Ort, förlag, år, upplaga, sidor
Stockholm: KTH Royal Institute of Technology, 2013. s. xx, 98
Serie
Trita-MEK, ISSN 0348-467X ; 2013:18
Nyckelord
Blood, Rheology, Viscosity, non-Newtonian, CFD, Bifurcations, Unsteadiness, Wall Shear Stress, Atherosclerosis
Nationell ämneskategori
Annan teknik
Identifikatorer
urn:nbn:se:kth:diva-136594 (URN)978-91-7501-952-9 (ISBN)
Disputation
2013-12-19, Sal F3, Lindstedtsvägen 26, KTH, Stockholm, 10:15 (Engelska)
Opponent
Handledare
Anmärkning

QC 20131206

Tillgänglig från: 2013-12-06 Skapad: 2013-12-06 Senast uppdaterad: 2013-12-06Bibliografiskt granskad

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Prahl-Wittberg, LisaMihaescu, Mihai

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Prahl-Wittberg, Lisavan Wyk, StevinMihaescu, MihaiFuchs, Laszlo
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BiomekanikLinné Flow Center, FLOWMekanik
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