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Binding modes of a core-extended metalloporphyrin to human telomeric DNA G-quadruplexes
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2015 (Engelska)Ingår i: Organic and biomolecular chemistry, ISSN 1477-0520, E-ISSN 1477-0539, Vol. 13, nr 8, s. 2453-2463Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The molecular recognition of human telomeric G-quadruplexes by a novel cationic π-extended NiII-porphyrin (NiII-TImidP4) is studied in aqueous solutions via (chir)optical spectroscopy, Fluorescence Resonance Energy Transfer (FRET) melting assay, and computational molecular modeling. The results are systematically compared with the recognition by a conventional meso-substituted NiII-porphyrin (NiII-TMPyP4), which allows us to pinpoint the differences in binding modes depending on the G-quadruplex topology. Importantly, FRET melting assays show the higher selectivity of NiII-TImidP4 towards human telomeric G4 than that of NiII-TMPyP4.

Ort, förlag, år, upplaga, sidor
Royal Society of Chemistry, 2015. Vol. 13, nr 8, s. 2453-2463
Nyckelord [en]
Assays, DNA sequences, Energy transfer, Fluorescence, Melting, Nickel, Porphyrins, Binding modes, Computational molecular modeling, Fluorescence resonance energy transfer, G-quadruplexes, Human telomeric DNA, Metalloporphyrins, Optical spectroscopy, Binding energy, guanine quadruplex, metalloporphyrin, binding site, chemical structure, chemistry, human, telomere, Binding Sites, Humans, Models, Molecular, Molecular Structure
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URN: urn:nbn:se:kth:diva-198716DOI: 10.1039/c4ob02097aISI: 000349669300033PubMedID: 25563845Scopus ID: 2-s2.0-84922791136OAI: oai:DiVA.org:kth-198716DiVA, id: diva2:1059123
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QC 20161222

Tillgänglig från: 2016-12-22 Skapad: 2016-12-21 Senast uppdaterad: 2017-11-29Bibliografiskt granskad

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Norman, Patrick
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Organic and biomolecular chemistry
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