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Solid nanofoams based on cellulose nanofibers and indomethacin—the effect of processing parameters and drug content on material structure
KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknologi. KTH, Skolan för kemivetenskap (CHE), Centra, Wallenberg Wood Science Center.
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2017 (Engelska)Ingår i: International Journal of Pharmaceutics, ISSN 0378-5173, E-ISSN 1873-3476, Vol. 526, nr 1-2, s. 291-299Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The unique colloidal properties of cellulose nanofibers (CNF), makes CNF a very interesting new excipient in pharmaceutical formulations, as CNF in combination with some poorly-soluble drugs can create nanofoams with closed cells. Previous nanofoams, created with the model drug indomethacin, demonstrated a prolonged release compared to films, owing to the tortuous diffusion path that the drug needs to take around the intact air-bubbles. However, the nanofoam was only obtained at a relatively low drug content of 21 wt% using fixed processing parameters. Herein, the effect of indomethacin content and processing parameters on the foaming properties was analysed. Results demonstrate that a certain amount of dissolved drug is needed to stabilize air-bubbles. At the same time, larger fractions of dissolved drug promote coarsening/collapse of the wet foam. The pendant drop/bubble profile tensiometry was used to verify the wet-foam stability at different pHs. The pH influenced the amount of solubilized drug and the processing-window was very narrow at high drug loadings. The results were compared to real foaming-experiments and solid state analysis of the final cellular solids. The parameters were assembled into a processing chart, highlighting the importance of the right combination of processing parameters (pH and time-point of pH adjustment) in order to successfully prepare cellular solid materials with up to 46 wt% drug loading.

Ort, förlag, år, upplaga, sidor
Elsevier, 2017. Vol. 526, nr 1-2, s. 291-299
Nyckelord [en]
Cellular solid material, Cellulose nanofibers, Indomethacin, Nanofoam, Poorly-soluble drugs
Nationell ämneskategori
Farmaceutiska vetenskaper
Identifikatorer
URN: urn:nbn:se:kth:diva-209536DOI: 10.1016/j.ijpharm.2017.04.041Scopus ID: 2-s2.0-85019091475OAI: oai:DiVA.org:kth-209536DiVA, id: diva2:1112536
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QC 20170620

Tillgänglig från: 2017-06-20 Skapad: 2017-06-20 Senast uppdaterad: 2018-01-13Bibliografiskt granskad

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Wohlert, JakobSvagan, Anna J.
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Fiber- och polymerteknologiWallenberg Wood Science Center
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International Journal of Pharmaceutics
Farmaceutiska vetenskaper

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