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Mechanistic insight into reactivity and (geno)toxicity of well-characterized nanoparticles of cobalt metal and oxides
Karolinska Inst, Inst Environm Med, Stockholm, Sweden..
KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap. Karolinska Inst, Inst Environm Med, Stockholm, Sweden.ORCID-id: 0000-0003-2145-3650
Karolinska Inst, Inst Environm Med, Stockholm, Sweden..
KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap.ORCID-id: 0000-0003-2100-8864
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2018 (Engelska)Ingår i: Nanotoxicology, ISSN 1743-5390, E-ISSN 1743-5404, Vol. 12, nr 6, s. 602-620Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

An increasing use of cobalt (Co)-based nanoparticles (NPs) in different applications and exposures at occupational settings triggers the need for toxicity assessment. Improved understanding regarding the physiochemical characteristics of Co metal NPs and different oxides in combination with assessment of toxicity and mechanisms may facilitate decisions for grouping during risk assessment. The aim of this study was to gain mechanistic insights in the correlation between NP reactivity and toxicity of three different Co-based NPs (Co, CoO, and Co3O4) by using various tools for characterization, traditional toxicity assays, as well as six reporter cell lines (ToxTracker) for rapid detection of signaling pathways of relevance for carcinogenicity. The results showed cellular uptake of all NPs in lung cells and induction of DNA strand breaks and oxidative damage (comet assay) by Co and CoO NPs. In-depth studies on the ROS generation showed high reactivity of Co, lower for CoO, and no reactivity of Co3O4 NPs. The reactivity depended on the corrosion and transformation/dissolution properties of the particles and the media highlighting the role of the surface oxide and metal speciation as also confirmed by in silico modeling. By using ToxTracker, Co NPs were shown to be highly cytotoxic and induced reporters related to oxidative stress (Nrf2 signaling) and DNA strand breaks. Similar effects were observed for CoO NPs but at higher concentrations, whereas the Co3O4 NPs were inactive at all concentrations tested. In conclusion, our study suggests that Co and CoO NPs, but not Co3O4, may be grouped together for risk assessment.

Ort, förlag, år, upplaga, sidor
Taylor & Francis, 2018. Vol. 12, nr 6, s. 602-620
Nyckelord [en]
Cobalt, nanomaterials, genotoxicity, risk assessment, grouping
Nationell ämneskategori
Annan kemi
Identifikatorer
URN: urn:nbn:se:kth:diva-240194DOI: 10.1080/17435390.2018.1470694ISI: 000439981600008PubMedID: 29790399Scopus ID: 2-s2.0-85047266606OAI: oai:DiVA.org:kth-240194DiVA, id: diva2:1270699
Forskningsfinansiär
Vetenskapsrådet, 2014-4598 2015-04177 2013-5621 2017-03931
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QC 20181214

Tillgänglig från: 2018-12-14 Skapad: 2018-12-14 Senast uppdaterad: 2018-12-14Bibliografiskt granskad

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Hedberg, YolandaHedberg, JonasOdnevall Wallinder, Inger

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