Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Physical crosslinking of hyaluronic acid in the presence of phospholipids in an aqueous nano-environment
UTP Univ Sci & Technol, Inst Math & Phys, Al Kaliskiego 7, PL-85796 Bydgoszcz, Poland..ORCID-id: 0000-0002-7505-6063
Gdansk Univ Technol, Atom & Opt Phys Div, Dept Atom Mol & Opt Phys, Fac Appl Phys & Math, Narutowicza 11-12, PL-80233 Gdansk, Poland..
KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap. RISE Res Inst Sweden, Box 5607, SE-11486 Stockholm, Sweden..ORCID-id: 0000-0002-2288-819X
KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Yt- och korrosionsvetenskap. RISE Res Inst Sweden, Box 5607, SE-11486 Stockholm, Sweden..ORCID-id: 0000-0002-3207-1570
Visa övriga samt affilieringar
2018 (Engelska)Ingår i: Soft Matter, ISSN 1744-683X, E-ISSN 1744-6848, Vol. 14, nr 44, s. 8997-9004Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Hyaluronic acid and phospholipids are two components in the synovial joint cavity that contribute to joint lubrication synergistically. Molecular dynamics simulations were performed and hydrogen bonds in hyaluronic acid were analyzed to identify specific sites that are responsible for its physical cross-linking. Two molecular masses of hyaluronic acid, 10 kDa and 160 kDa, were considered. We use molecular dynamics simulations and the small world network approach to investigate dynamic couplings using a distance map applied to oxygen atoms in a chain of hyaluronic acid in the presence of phospholipids and water. The distance characterizing the coupling can be defined in various ways to bring out the most evident differences between various scenarios of the polymer chain conformation We show herein a physical distance understood as H-bond length and classes of these distances which are defined in a coarse-grained picture of the molecule. Simulation results indicate that addition of phospholipids has little influence on hyaluronic acid crosslinking. However, longer chains and addition of lipids promote appreciably long lasting (resilient) networks that may be of importance in biological systems. Specific sites for hydrogen bonding of phospholipids to hyaluronic acid have also been identified.

Ort, förlag, år, upplaga, sidor
ROYAL SOC CHEMISTRY , 2018. Vol. 14, nr 44, s. 8997-9004
Nationell ämneskategori
Korrosionsteknik
Identifikatorer
URN: urn:nbn:se:kth:diva-239758DOI: 10.1039/c8sm01388hISI: 000450442300013PubMedID: 30394485Scopus ID: 2-s2.0-85056530941OAI: oai:DiVA.org:kth-239758DiVA, id: diva2:1277152
Anmärkning

QC 20190109

Tillgänglig från: 2019-01-09 Skapad: 2019-01-09 Senast uppdaterad: 2019-01-09Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltextPubMedScopus

Personposter BETA

Dédinaité, AndraClaesson, Per M.

Sök vidare i DiVA

Av författaren/redaktören
Beldowski, PiotrDédinaité, AndraClaesson, Per M.Gadomski, Adam
Av organisationen
Yt- och korrosionsvetenskap
I samma tidskrift
Soft Matter
Korrosionsteknik

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 546 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf