Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
An ingestible self-orienting system for oral delivery of macromolecules
MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA..
MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA.;MIT, Inst Med Engn & Sci, 77 Massachusetts Ave, Cambridge, MA 02139 USA..ORCID-id: 0000-0002-2844-7598
MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA..
MIT, Inst Med Engn & Sci, 77 Massachusetts Ave, Cambridge, MA 02139 USA..
Visa övriga samt affilieringar
2019 (Engelska)Ingår i: Science, ISSN 0036-8075, E-ISSN 1095-9203, Vol. 363, nr 6427, s. 611-+Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Biomacromolecules have transformed our capacity to effectively treat diseases; however, their rapid degradation and poor absorption in the gastrointestinal (GI) tract generally limit their administration to parenteral routes. An oral biologic delivery system must aid in both localization and permeation to achieve systemic drug uptake. Inspired by the leopard tortoise's ability to passively reorient, we developed an ingestible self-orienting millimeter-scale applicator (SOMA) that autonomously positions itself to engage with GI tissue. It then deploys milliposts fabricated from active pharmaceutical ingredients directly through the gastric mucosa while avoiding perforation. We conducted in vivo studies in rats and swine that support the applicator's safety and, using insulin as a model drug, demonstrated that the SOMA delivers active pharmaceutical ingredient plasma levels comparable to those achieved with subcutaneous millipost administration.

Ort, förlag, år, upplaga, sidor
AMER ASSOC ADVANCEMENT SCIENCE , 2019. Vol. 363, nr 6427, s. 611-+
Nationell ämneskategori
Farmaceutiska vetenskaper
Identifikatorer
URN: urn:nbn:se:kth:diva-244513DOI: 10.1126/science.aau2277ISI: 000458114200044PubMedID: 30733413Scopus ID: 2-s2.0-85061192140OAI: oai:DiVA.org:kth-244513DiVA, id: diva2:1301729
Anmärkning

QC 20190402

Tillgänglig från: 2019-04-02 Skapad: 2019-04-02 Senast uppdaterad: 2019-04-04Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltextPubMedScopus

Personposter BETA

Roxhed, Niclas

Sök vidare i DiVA

Av författaren/redaktören
Caffarel-Salvador, EsterSilverstein, DavidRoxhed, Niclas
Av organisationen
Mikro- och nanosystemteknik
I samma tidskrift
Science
Farmaceutiska vetenskaper

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 660 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf