Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Investigation into the mechanism of solution-mediated transformation from FI to FIII carbamazepine: The role of dissolution and the interaction between polymorph surfaces
Visa övriga samt affilieringar
2013 (Engelska)Ingår i: Crystal Growth and Design, Vol. 13, nr 5, s. 1861-1871Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The solution mediated polymorphic transformation (SMPT) of the pharmaceutical compound carbamazepine was investigated in ethanol. Bulk transformation experiments were performed by monitoring the solution concentration and polymorphic composition over time during the transformation from the metastable FI polymorph to the stable FIII polymorph for a variety of initial conditions. Microscopic techniques, single-crystal X-ray diffraction, and computational methods were used to analyze the transformation. The nucleating behavior of the stable FIII polymorph was a significant factor affecting the transformation time across the range of experiments. The surfaces of the metastable FI particles were responsible for the nucleation of FIII during the transformation. However, no specific lattice matching or epitaxy was conclusively identified. A modest amount of dissolution of the FI particles was found to favor the nucleation of FIII but where extensive dissolution or no significant dissolution occurred this had a negative effect on the nucleation of FIII. 

Ort, förlag, år, upplaga, sidor
2013. Vol. 13, nr 5, s. 1861-1871
Nationell ämneskategori
Kemi
Identifikatorer
URN: urn:nbn:se:kth:diva-260456DOI: 10.1021/cg301456mISI: 000318468400009Scopus ID: 2-s2.0-84877048169OAI: oai:DiVA.org:kth-260456DiVA, id: diva2:1355634
Anmärkning

QC 20190930

Tillgänglig från: 2019-09-30 Skapad: 2019-09-30 Senast uppdaterad: 2019-09-30Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltextScopus

Personposter BETA

Rasmuson, Åke C.

Sök vidare i DiVA

Av författaren/redaktören
Rasmuson, Åke C.
Kemi

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetricpoäng

doi
urn-nbn
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf