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Dual-drug delivery of Ag-chitosan nanoparticles and phenytoin via core-shell PVA/PCL electrospun nanofibers
Univ Hosp RWTH Aachen, Dermatol Clin, D-52074 Aachen, Germany.;Natl Res Ctr, Div Med Res, Dept Pharmacol, Cairo 12622, Egypt..
Marmara Univ, Ctr Nanotechnol & Biomat Applicat & Res NBUAM, TR-34722 Istanbul, Turkey.;Marmara Univ, Dept Pharmacol, Fac Pharm, TR-34716 Istanbul, Turkey..
Marmara Univ, Dept Pharmaceut Microbiol, Istanbul, Turkey..
Marmara Univ, Ctr Nanotechnol & Biomat Applicat & Res NBUAM, TR-34722 Istanbul, Turkey.;Marmara Univ, Dept Pharmacol, Fac Pharm, TR-34716 Istanbul, Turkey.;UCL, Dept Mech Engn, Torrington Pl, London W E 7JE, England..
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2021 (Engelska)Ingår i: Carbohydrate Polymers, ISSN 0144-8617, E-ISSN 1879-1344, Vol. 270, artikel-id 118373Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Dual-drug delivery systems were constructed through coaxial techniques, which were convenient for the model drugs used the present work. This study aimed to fabricate core-shell electrospun nanofibrous membranes displaying simultaneous cell proliferation and antibacterial activity. For that purpose, phenytoin (Ph), a well-known proliferative agent, was loaded into a polycaprolactone (PCL) shell membrane, and as-prepared silver-chitosan nanoparticles (Ag-CS NPs), as biocidal agents, were embedded in a polyvinyl alcohol (PVA) core layer. The morphology, chemical composition, mechanical and thermal properties of the nanofibrous membranes were characterized by FESEM/STEM, FTIR and DSC. The coaxial PVA-Ag CS NPs/PCL-Ph nanofibers (NFs) showed more controlled Ph release than PVA/PCL-Ph NFs. There was notable improvement in the morphology, thermal, mechanical, antibacterial properties and cytobiocompatibility of the fibers upon incorporation of Ph and Ag-CS NPs. The proposed core-shell PVA/PCL NFs represent promising scaffolds for tissue regeneration and wound healing by the effective dual delivery of phenytoin and Ag-CS NPs.

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Elsevier BV , 2021. Vol. 270, artikel-id 118373
Nyckelord [en]
Silver nanoparticles, Chitosan, Phenytoin, Dual-drug delivery, Core-shell nanofibers
Nationell ämneskategori
Biomaterial
Identifikatorer
URN: urn:nbn:se:kth:diva-300952DOI: 10.1016/j.carbpol.2021.118373ISI: 000685904300002PubMedID: 34364617Scopus ID: 2-s2.0-85110785381OAI: oai:DiVA.org:kth-300952DiVA, id: diva2:1590843
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QC 20210903

Tillgänglig från: 2021-09-03 Skapad: 2021-09-03 Senast uppdaterad: 2022-09-07Bibliografiskt granskad

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Muhammed, Mamoun

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Sahin, AliMuhammed, Mamoun
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