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Does early EBV infection protect against IgE sensitization?
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2005 (Engelska)Ingår i: Journal of Allergy and Clinical Immunology, ISSN 0091-6749, E-ISSN 1097-6825, Vol. 116, nr 2, s. 438-444Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: There is indirect evidence that an increased infectious burden is associated with a decreased prevalence of IgE-mediated allergy during childhood. Objective: To determine whether there is a relation between the serostatus of 13 different viruses and parentally reported infections and IgE sensitization in 2-year-old children. To investigate whether there is an interaction between cytomegalovirus (CMV) and Epstein-Barr virus (EBV) in relation to IgE sensitization. Methods: A total of 246 infants were followed prospectively to 2 years of age with clinical examinations, skin prick test, and specific IgE analyses and through analysis of seropositivity against adenovirus, influenza, parainfluenza, respiratory syncytial virus, CMV, EBV, herpes simplex virus, human herpesvirus 6, and varicella-zoster virus. Results: There was some evidence that IgE sensitization (24%) tended to be more common among children who were seropositive against few compared with children who were seropositive against many viruses, but this was not statistically significant, and there was no consistent trend across the groups. IgE sensitization was statistically significantly less prevalent at 2 years of age among infants who were seropositive against EBV but not other viruses (adjusted odds ratio, 0.34; 95% CI, 0.14-0.86). The interaction of seropositivity against both CMV and EBV antibodies indicated a further reduction in the risk for IgE sensitization (adjusted odds ratio for interaction, 0.10; 95% CI, 0.01-0.92), indicating effect modification associated with seropositivity against CMV. Conclusion: Our results indicate that acquisition of EBV infection during the first 2 years of life is associated with a reduced risk of IgE sensitization, and this effect is enhanced by CMV coinfection.

Ort, förlag, år, upplaga, sidor
2005. Vol. 116, nr 2, s. 438-444
Nyckelord [en]
childhood, CMV, EBV, IgE, infections, sensitization, serology, viral infections, barr-virus-infection, cytomegalovirus-infection, early-childhood, atopic disease, cord blood, antibodies, children, cells, life, schoolchildren
Identifikatorer
URN: urn:nbn:se:kth:diva-15326DOI: 10.1016/j.jaci.2005.04.027ISI: 000235686400031Scopus ID: 2-s2.0-23244448469OAI: oai:DiVA.org:kth-15326DiVA, id: diva2:333367
Anmärkning
QC 20100525Tillgänglig från: 2010-08-05 Skapad: 2010-08-05 Senast uppdaterad: 2017-12-12Bibliografiskt granskad
Ingår i avhandling
1. Risk, Risk Analysis and Decision-making with Reference to Biostatistics and the Field of Medicine
Öppna denna publikation i ny flik eller fönster >>Risk, Risk Analysis and Decision-making with Reference to Biostatistics and the Field of Medicine
2010 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

Risk, risk analysis and decision-making are essential aspects of health care andmedicine, for patients as well as for physicians and for society as a whole, andthe concept of risk and risk analysis in decision-making has a long history. Theword risk has many different interpretations and has no commonly accepteddefinition. In this thesis, we shall let risk stand for the combination of randomor uncertain events with negative consequences for human health, life and/orwelfare and/or the environment together with some measures of the likelihoodof such events. We believe this is the dominant concept and understanding ofrisk, the risk being the likelihood or probability of an event followed by somenegative consequences or activities of that event.

In this doctoral thesis, we focus on biostatistics, risks and risk analysis in thefield of medicine, a science which has been using methods from the area of riskanalysis for a long time. The seven papers (paper I - paper VII) presented inthis thesis, together with a general introduction to risk, risk analysis anddecision-making, will be used to illustrate and discuss risk analysis as a tool fordecision-making in the field of medicine. From my point a view, risk analysisin the field of medicine aims to reduce pain, raise the quality of life, reduce therisk of adverse events, compare cost efficiency between different treatmentregimes and prolong a healthy life. Based on results presented in the thesis, weconclude that biostatistics, risks and risk analysis used in the field of medicineare valuable methods for evaluation of hypotheses within the health care areaand a good basis for decision-making.

Ort, förlag, år, upplaga, sidor
Stockholm: KTH Royal Institute of Technology, 2010. s. 51
Serie
TRITA-TEC-PHD, ISSN 1653-4468 ; 10:004
Nyckelord
risk analysis, risk, consequence, system, biostatistics, decision, decision-making, health care, medicine
Nationell ämneskategori
Medicinsk laboratorie- och mätteknik
Identifikatorer
urn:nbn:se:kth:diva-24304 (URN)978-91-85539-62-8 (ISBN)
Disputation
2010-09-15, F3, Lindstedtsvägen 26, KTH, Stockholm, 10:15 (Engelska)
Opponent
Handledare
Anmärkning

QC 20100901

Tillgänglig från: 2010-09-01 Skapad: 2010-09-01 Senast uppdaterad: 2017-02-22Bibliografiskt granskad

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