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Intracellular dynamics of calcyon, a neuron-specific vesicular protein
KTH, Skolan för teknikvetenskap (SCI), Tillämpad fysik, Cellens fysik.ORCID-id: 0000-0003-0578-4003
2007 (Engelska)Ingår i: NeuroReport, ISSN 0959-4965, E-ISSN 1473-558X, Vol. 18, nr 15, s. 1547-1551Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Calcyon is a brain-specific protein, implicated in clathrin-mediated endocytosis. In this descriptive study we show that calcyon is exclusively expressed in neurons, and localized in moving vesicles. The movement of calcyon-containing vesicles was dependent on temperature and on intact microtubules, in addition these vesicles were colocalized with a marker for endocytosed plasma membrane proteins, suggesting that calcyon vesicles follow the endocytic recycling pathway. We also show using evanescent wave microscopy that there is a pool of ready releasable calcyon vesiclesaccumulated beneath the plasma membrane. We conclude that the mobility and storage properties of calcyon-containing vesicles imply that they play a role in brain plasticity.

Ort, förlag, år, upplaga, sidor
2007. Vol. 18, nr 15, s. 1547-1551
Nyckelord [en]
calcyon, endocytic recycling pathway, total internal reflection fluorescence microscopy, vesicles, receptors, endocytosis, activation, expression, spines, brain, ltp
Identifikatorer
URN: urn:nbn:se:kth:diva-16996ISI: 000249853200009Scopus ID: 2-s2.0-34748818773OAI: oai:DiVA.org:kth-16996DiVA, id: diva2:335039
Anmärkning
QC 20100525Tillgänglig från: 2010-08-05 Skapad: 2010-08-05 Senast uppdaterad: 2017-12-12Bibliografiskt granskad

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Brismar, Hjalmar

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