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Novel biochemical markers of psychosocial stress in women
Karolinska Institutet.
Karolinska Institutet.
Karolinska Institutet.
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2009 (Engelska)Ingår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 4, nr 1, s. e3590-Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

BACKGROUND: Prolonged psychosocial stress is a condition assessed through self-reports. Here we aimed to identify biochemical markers for screening and early intervention in women.

METHODS: Plasma concentrations of interleukin (IL) 1-alpha, IL1-beta, IL-2, IL-4, IL-6, IL-8, IL-10, interferon-gamma (INF-gamma), tumor necrosis factor-alpha (TNF-alpha), monocyte chemotactic protein-1 (MCP-1), epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), thyroid stimulating hormone (TSH), total tri-iodothyronine (TT3), total thyroxine (TT4), prolactin, and testosterone were measured in: 195 women on long-term sick-leave for a stress-related affective disorder, 45 women at risk for professional burnout, and 84 healthy women.

RESULTS: We found significantly increased levels of MCP-1, VEGF and EGF in women exposed to prolonged psychosocial stress. Statistical analysis indicates that they independently associate with a significant risk for being classified as ill.

CONCLUSIONS: MCP-1, EGF, and VEGF are potential markers for screening and early intervention in women under prolonged psychosocial stress.

Ort, förlag, år, upplaga, sidor
2009. Vol. 4, nr 1, s. e3590-
Nyckelord [en]
EPIDERMAL-GROWTH-FACTOR, BIOCHIP ARRAY TECHNOLOGY, NF-KAPPA-B, SLEEP, DISORDERS, CYTOKINES, PATHWAYS, CORTISOL, RHYTHMS, BURNOUT
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
URN: urn:nbn:se:kth:diva-87243DOI: 10.1371/journal.pone.0003590ISI: 000274089700001PubMedID: 19177163OAI: oai:DiVA.org:kth-87243DiVA, id: diva2:502607
Anmärkning
QC 20120216Tillgänglig från: 2012-02-14 Skapad: 2012-02-14 Senast uppdaterad: 2017-12-07Bibliografiskt granskad

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Wilczek, LukasEkstedt, Mirjam
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