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The genomics of selection in dogs and the parallel evolution between dogs and humans
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2013 (Engelska)Ingår i: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 4, s. 1860-Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The genetic bases of demographic changes and artificial selection underlying domestication are of great interest in evolutionary biology. Here we perform whole-genome sequencing of multiple grey wolves, Chinese indigenous dogs and dogs of diverse breeds. Demographic analysis show that the split between wolves and Chinese indigenous dogs occurred 32,000 years ago and that the subsequent bottlenecks were mild. Therefore, dogs may have been under human selection over a much longer time than previously concluded, based on molecular data, perhaps by initially scavenging with humans. Population genetic analysis identifies a list of genes under positive selection during domestication, which overlaps extensively with the corresponding list of positively selected genes in humans. Parallel evolution is most apparent in genes for digestion and metabolism, neurological process and cancer. Our study, for the first time, draws together humans and dogs in their recent genomic evolution.

Ort, förlag, år, upplaga, sidor
Nature Publishing Group, 2013. Vol. 4, s. 1860-
Nyckelord [en]
animal experiment, article, biological phenomena and functions concerning the entire organism, breed, Chinese, controlled study, demography, digestion, dog, domestication, evolution, gene sequence, genetic selection, genomics, human, human genome, metabolism, neoplasm, neurology, nonhuman
Nationell ämneskategori
Biologiska vetenskaper
Identifikatorer
URN: urn:nbn:se:kth:diva-124994DOI: 10.1038/ncomms2814ISI: 000320589900056Scopus ID: 2-s2.0-84878742437OAI: oai:DiVA.org:kth-124994DiVA, id: diva2:638976
Forskningsfinansiär
Knut och Alice Wallenbergs StiftelseScience for Life Laboratory - a national resource center for high-throughput molecular bioscience
Anmärkning

QC 20130805

Tillgänglig från: 2013-08-05 Skapad: 2013-08-02 Senast uppdaterad: 2017-12-06Bibliografiskt granskad

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Savolainen, Peter

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Savolainen, Peter
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GenteknologiScience for Life Laboratory, SciLifeLab
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