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The early diastolic myocardial velocity: A marker of increased risk in patients with coronary heart disease
KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinsk bildteknik.ORCID-id: 0000-0002-5156-2535
KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik. Karolinska Institute, Sweden.
KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinsk bildteknik.
KTH, Skolan för teknik och hälsa (STH), Medicinsk teknik, Medicinsk bildteknik.
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2014 (Engelska)Ingår i: Clinical Physiology and Functional Imaging, ISSN 1475-0961, E-ISSN 1475-097X, Vol. 34, nr 5, s. 389-396Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objective: Tissue Doppler imaging (TDI) is a promising echocardiographic modality allowing quantification of myocardial performance. However, the prognostic potential of TDI in patients with acute myocardial infarction (AMI) is not yet investigated. We sought to explore the ability of TDI in identifying patients at risk for new cardiovascular events after AMI. Methods: One hundred and nineteen patients with AMI were recruited prospectively (mean age 61 years; range 32-81 years of age). Patients with diabetes mellitus (DM) were excluded. Echocardiography was performed 3-12 months after AMI. Two-dimensional (2-D) and TDI variables were recorded. The patients were followed during a mean period of 4·6 years (range 1-8 years). The primary end-point was defined as any of the following: death from any cause, non-fatal reinfarction or stroke, unstable angina pectoris, congestive heart failure requiring hospitalization and coronary revascularization procedure. Results: Thirty patients had some form of cardiovascular events during follow-up. Seven patients had cardiovascular death, 13 patients had reinfarction and four patients had a stroke. New angina or unstable angina was recorded in 21 patients. Of these patients, 13 underwent percutaneous coronary angioplasty (PCI) or coronary artery bypass grafting (CABG). The early diastolic myocardial velocity (Em) emerged as the only echocardiographic variable that offered a clear differentiation between patients that presented with new cardiovascular (CV) events as compared to the corresponding group without any CV events at follow-up (P<0·05). In multivariate statistical analysis and after adjustment for age, sex, total cholesterol, body mass index (BMI) and other baseline characteristics, Em remained as independent predictors of CV events (HR, 1·18, 95% CI, 1·02-1·36; P<0·05). However, none of the investigated variables evolved as an independent predictor of cardiovascular morbidity and mortality. Conclusion: Em appears to be a sensitive echocardiographic index in identifying non-diabetic patients with AMI at risk of new cardiovascular events.

Ort, förlag, år, upplaga, sidor
2014. Vol. 34, nr 5, s. 389-396
Nyckelord [en]
Early myocardial diastolic velocity, Myocardial infarction, Tissue velocity imaging
Nationell ämneskategori
Medicinsk bildbehandling
Identifikatorer
URN: urn:nbn:se:kth:diva-151043DOI: 10.1111/cpf.12110ISI: 000341238500008Scopus ID: 2-s2.0-84908356117OAI: oai:DiVA.org:kth-151043DiVA, id: diva2:747064
Anmärkning

QC 20140915

Tillgänglig från: 2014-09-15 Skapad: 2014-09-15 Senast uppdaterad: 2017-12-05Bibliografiskt granskad
Ingår i avhandling
1. The Cardiac State Diagram: A new method for assessing cardiac mechanics
Öppna denna publikation i ny flik eller fönster >>The Cardiac State Diagram: A new method for assessing cardiac mechanics
2015 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Ort, förlag, år, upplaga, sidor
Stockholm: KTH Royal Institute of Technology, 2015. s. 107
Serie
TRITA-STH ; 2015:2
Nyckelord
Cardiac State Diagram, Heart, Hydraulic, Mechanics, DAPP, DeltaV, Hydraulic forces, left ventricular, diastole
Nationell ämneskategori
Teknik och teknologier
Forskningsämne
Tillämpad medicinsk teknik
Identifikatorer
urn:nbn:se:kth:diva-202743 (URN)978-91-7595-477-6 (ISBN)
Disputation
2015-04-27, 3-221, Alfred Nobels Alle10, Huddinge, 15:57 (Svenska)
Opponent
Handledare
Anmärkning

QC 20170306

Tillgänglig från: 2017-03-06 Skapad: 2017-03-04 Senast uppdaterad: 2017-03-06Bibliografiskt granskad

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Johnson, Jonas

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Johnson, JonasManouras, AristomenisBergholm, FredrikBrodin, Lars Åke
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