Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
New paradigms for metabolic modeling of human cells
KTH, Centra, Science for Life Laboratory, SciLifeLab.
2015 (Engelska)Ingår i: Current Opinion in Biotechnology, ISSN 0958-1669, E-ISSN 1879-0429, Vol. 34, s. 91-97Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Abnormalities in cellular functions are associated with the progression of human diseases, often resulting in metabolic reprogramming. GEnome-scale metabolic Models (GEMs) have enabled studying global metabolic reprogramming in connection with disease development in a systematic manner. Here we review recent work on reconstruction of GEMs for human cell/tissue types and cancer, and the use of GEMs for identification of metabolic changes occurring in response to disease development. We further discuss how GEMs can be used for the development of efficient therapeutic strategies. Finally, challenges in integration of cell/tissue models for simulation of whole body functions as well as integration of GEMs with other biological networks for generating complete cell/tissue models are presented.

Ort, förlag, år, upplaga, sidor
2015. Vol. 34, s. 91-97
Nyckelord [en]
Bioinformatics, Cells, Cytology, Gems, Biological networks, Cellular function, Disease development, Genome scale metabolic model, Human disease, Metabolic changes, Metabolic modeling, Therapeutic strategy, Metabolism, biological model, cell metabolism, disease course, gene expression, human, intestine flora, metabolomics, proteomics, Review, simulation, tissue metabolism, transcriptomics, tumor growth
Nationell ämneskategori
Medicinsk bioteknologi
Identifikatorer
URN: urn:nbn:se:kth:diva-167688DOI: 10.1016/j.copbio.2014.12.013Scopus ID: 2-s2.0-84920286423OAI: oai:DiVA.org:kth-167688DiVA, id: diva2:816088
Anmärkning

QC 20150602

Tillgänglig från: 2015-06-02 Skapad: 2015-05-22 Senast uppdaterad: 2017-12-04Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltextScopus

Sök vidare i DiVA

Av författaren/redaktören
Nielsen, Jens Brehm Bagger
Av organisationen
Science for Life Laboratory, SciLifeLab
I samma tidskrift
Current Opinion in Biotechnology
Medicinsk bioteknologi

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetricpoäng

doi
urn-nbn
Totalt: 36 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf