Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Effect of the dissolution time into an acid hydrolytic solvent to taylor electrospun nanofibrous polycaprolactone scaffolds
KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknologi.ORCID-id: 0000-0002-2139-7460
KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknologi. Skövde University, Sweden.ORCID-id: 0000-0002-5394-7850
Vise andre og tillknytning
2017 (engelsk)Inngår i: European Polymer Journal, ISSN 0014-3057, E-ISSN 1873-1945, Vol. 87, s. 174-187Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The hydrolysis of the polycaprolactone (PCL) as a function of the dissolution time in a formic/acetic acid mixture was considered as a method for tailoring the morphology of nanofibrous PCL scaffolds. Hence, the aim of this research was to establish a correlation between the dissolution time of the polymer in the acid solvent with the physico-chemical properties of the electrospun nanofibrous scaffolds and their further service life behaviour. The physico-chemical properties of the scaffolds were assessed in terms of fibre morphology, molar mass and thermal behaviour. A reduction of the molar mass and the lamellar thickness as well as an increase of the crystallinity degree were observed as a function of dissolution time. Bead-free fibres were found after 24 and 48 h of dissolution time, with similar diameter distributions. The decrease of the fibre diameter distributions along with the apparition of beads was especially significant for scaffolds prepared after 72 h and 120 h of dissolution time in the acid mixture. The service life of the obtained devices was evaluated by means of in vitro validation under abiotic physiological conditions. All the scaffolds maintained the nanofibrous structure after 100 days of immersion in water and PBS. The molar mass was barely affected and the crystallinity degree and the lamellar thickness increased along immersion, preventing scaffolds from degradation. Scaffolds prepared after 24 h and 48 h kept their fibre diameters, whereas those prepared after 72 h and 120 h showed a significant reduction. This PCL tailoring procedure to obtain scaffolds that maintain the nanoscaled structure after such long in vitro evaluation will bring new opportunities in the design of long-term biomedical patches.

sted, utgiver, år, opplag, sider
Elsevier, 2017. Vol. 87, s. 174-187
Emneord [en]
Electrospinning, Hydrolysis, In vitro validation, Polycaprolactone (PCL), Scaffold, Chemical properties, Dissolution, Fibers, Mixtures, Molar mass, Nanofibers, Polycaprolactone, Crystallinity degree, Diameter distributions, In-vitro, Nano-scaled structures, Nanofibrous scaffolds, Physicochemical property, Physiological condition, Polycaprolactone scaffolds, Scaffolds
HSV kategori
Identifikatorer
URN: urn:nbn:se:kth:diva-201951DOI: 10.1016/j.eurpolymj.2016.12.005ISI: 000395210900015Scopus ID: 2-s2.0-85007427983OAI: oai:DiVA.org:kth-201951DiVA, id: diva2:1078426
Merknad

Funding text: The European Regional Development Funds and the Spanish Ministry of Economy and Competitiveness are acknowledged for the projects POLYCELL (ENE2014-53734-C2-1-R) and UPOV13-3E-1947. The Spanish Ministry of Education, Culture and Sports is thanked for the pre-doctoral FPU grant of O. Gil-Castell (FPU13/01916) and the scholarship for a research stage of O. Gil-Castell in Kungliga Tekniska Högskolan (KTH). Generalitat Valenciana is thanked for the APOSTD/2014/041 for J.D. Badia. Universitat de València (UV) and IIS LaFe are acknowledged for the DERMASAFE project. The financial support given by the KTH Royal Institute of Technology and the Universitat Politècnica de València (UPV) are gratefully acknowledged. IESMAT S.A. and Malvern Instruments Ltd are recognised for their grateful collaboration.

QC 20170303

Tilgjengelig fra: 2017-03-03 Laget: 2017-03-03 Sist oppdatert: 2017-11-29bibliografisk kontrollert

Open Access i DiVA

Fulltekst mangler i DiVA

Andre lenker

Forlagets fulltekstScopus

Personposter BETA

Strömberg, EmmaKarlsson, Sigbritt

Søk i DiVA

Av forfatter/redaktør
Strömberg, EmmaKarlsson, Sigbritt
Av organisasjonen
I samme tidsskrift
European Polymer Journal

Søk utenfor DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric

doi
urn-nbn
Totalt: 135 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf