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Multirate method for co-simulation of electrical-chemical systems in multiscale modeling
KTH, Centra, Science for Life Laboratory, SciLifeLab.
KTH, Skolan för datavetenskap och kommunikation (CSC), Beräkningsvetenskap och beräkningsteknik (CST).ORCID-id: 0000-0002-0550-0739
Vise andre og tillknytning
2017 (engelsk)Inngår i: Journal of Computational Neuroscience, ISSN 0929-5313, E-ISSN 1573-6873, Vol. 42, nr 3, s. 245-256Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Multiscale modeling by means of co-simulation is a powerful tool to address many vital questions in neuroscience. It can for example be applied in the study of the process of learning and memory formation in the brain. At the same time the co-simulation technique makes it possible to take advantage of interoperability between existing tools and multi-physics models as well as distributed computing. However, the theoretical basis for multiscale modeling is not sufficiently understood. There is, for example, a need of efficient and accurate numerical methods for time integration. When time constants of model components are different by several orders of magnitude, individual dynamics and mathematical definitions of each component all together impose stability, accuracy and efficiency challenges for the time integrator. Following our numerical investigations in Brocke et al. (Frontiers in Computational Neuroscience, 10, 97, 2016), we present a new multirate algorithm that allows us to handle each component of a large system with a step size appropriate to its time scale. We take care of error estimates in a recursive manner allowing individual components to follow their discretization time course while keeping numerical error within acceptable bounds. The method is developed with an ultimate goal of minimizing the communication between the components. Thus it is especially suitable for co-simulations. Our preliminary results support our confidence that the multirate approach can be used in the class of problems we are interested in. We show that the dynamics ofa communication signal as well as an appropriate choice of the discretization order between system components may have a significant impact on the accuracy of the coupled simulation. Although, the ideas presented in the paper have only been tested on a single model, it is likely that they can be applied to other problems without loss of generality. We believe that this work may significantly contribute to the establishment of a firm theoretical basis and to the development of an efficient computational framework for multiscale modeling and simulations.

sted, utgiver, år, opplag, sider
Springer-Verlag New York, 2017. Vol. 42, nr 3, s. 245-256
Emneord [en]
Adaptive time step integration, Backward differentiation formula, Co-simulation, Coupled integration, Coupled system, Multirate integration, Multiscale modeling, Multiscale simulation, Parallel numerical integration
HSV kategori
Identifikatorer
URN: urn:nbn:se:kth:diva-207312DOI: 10.1007/s10827-017-0639-7ISI: 000400077500003Scopus ID: 2-s2.0-85017136818OAI: oai:DiVA.org:kth-207312DiVA, id: diva2:1107313
Forskningsfinansiär
EU, FP7, Seventh Framework Programme, 604102EU, Horizon 2020, 720270Swedish Research CouncilSwedish e‐Science Research CenterScience for Life Laboratory - a national resource center for high-throughput molecular bioscience
Merknad

QC 20170609

Tilgjengelig fra: 2017-06-09 Laget: 2017-06-09 Sist oppdatert: 2018-01-13bibliografisk kontrollert

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Hellgren Kotaleski, JeanetteHanke, Michael

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