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Redox-Responsive and Calcium-Dependent Switching of Glycosyldisulfide Interactions with Concanavalin A
KTH, Skolan för kemivetenskap (CHE), Kemi.
KTH, Skolan för kemivetenskap (CHE), Kemi.ORCID-id: 0000-0002-1533-6514
2005 (Engelska)Ingår i: Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, E-ISSN 1090-2120, Vol. 15, s. 2707-2710Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Glycosyldisulfides can interact efficiently with carbohydrate-binding entities. This has been shown for a range of thiosaccharide dimers when tested for their effects against the lectin Concanavalin A using a modified quartz crystal microbalance-technique. Contrary to the thiosaccharide monomers, showing no significant binding up to 10 mM, several of the dimers showed IC50-values in the low millimolar range. Three of the glycosyldisulfides tested also displayed very high positive apparent cooperativity effects that were found to be both calcium-dependent and redox-responsive.

Ort, förlag, år, upplaga, sidor
2005. Vol. 15, s. 2707-2710
Nyckelord [en]
dynamic chemistry, glycochemistry, molecular recognition, lectins, thiosaccharides, quartz crystal microbalance
Nationell ämneskategori
Organisk kemi
Identifikatorer
URN: urn:nbn:se:kth:diva-6391DOI: 10.1016/j.bmcl.2005.04.024ISI: 000229665600001PubMedID: 15878660Scopus ID: 2-s2.0-19544365923OAI: oai:DiVA.org:kth-6391DiVA, id: diva2:11087
Anmärkning
QC 20100915Tillgänglig från: 2006-11-22 Skapad: 2006-11-22 Senast uppdaterad: 2020-03-09Bibliografiskt granskad
Ingår i avhandling
1. Carbohydrate Synthesis and Study of Carbohydrate-Lectin Interactions Using QCM Biosensors and Microarray Technologies
Öppna denna publikation i ny flik eller fönster >>Carbohydrate Synthesis and Study of Carbohydrate-Lectin Interactions Using QCM Biosensors and Microarray Technologies
2006 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

Interactions between carbohydrates and proteins are increasingly being recognized as crucial in many biological processes, such as cellular adhesion and communication. In order to investigate the interactions of carbohydrates and proteins, the development of efficient analytic technologies, as well as novel strategies for the synthesis of carbohydrates, have to be explored. To date, several methods have been exploited to analyze interactions of carbohydrates and proteins, for example, biosensors, nuclear magnetic resonance (NMR); enzyme-linked immunosorbent assays (ELISA), X-ray crystallography and array technologies. This thesis describes the development of novel strategies for the synthesis of carbohydrates, as well as new efficient strategies to Quartz Crystal Microbalance- (QCM-) biosensors and carbohydrate microarrays technologies. These methodologies have been used to probe carbohydrate-lectin-interactions for a range of plant and animal lectins.

Ort, förlag, år, upplaga, sidor
Stockholm: KTH, 2006. s. 106
Serie
Trita-IOK, ISSN 1100-7974 ; 2006:106
Nyckelord
Lectins; Carbohydrates; Molecular recognition; Biosensors; Quartz crystal microbalance; Carbohydrate microarrays.
Nationell ämneskategori
Organisk kemi
Identifikatorer
urn:nbn:se:kth:diva-4177 (URN)91-7178-503-5 (ISBN)
Disputation
2006-12-01, D3, Lindstedtsvägen 5, Stockholm, 10:00
Opponent
Handledare
Anmärkning
QC 20100915Tillgänglig från: 2006-11-22 Skapad: 2006-11-22 Senast uppdaterad: 2019-12-20Bibliografiskt granskad

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Förlagets fulltextPubMedScopushttp://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TF9-4G3KBT4-4&_user=4478132&_coverDate=06%2F02%2F2005&_alid=493490083&_rdoc=1&_fmt=summary&_orig=search&_cdi=5221&_sort=d&_docanchor=&view=c&_acct=C000034958&_version=1&_urlVersion=0&_userid=4478132&md5=97afbd5378bcef35830c01cf9eaf1928

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