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Bed rest and hypoxic exposure affect sleep architecture and breathing stability
KTH, Skolan för teknik och hälsa (STH), Omgivningsfysiologi. Swedish Aerospace Physiology Centre.
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2017 (Engelska)Ingår i: Frontiers in Physiology, ISSN 1664-042X, E-ISSN 1664-042X, Vol. 8, nr June, artikel-id 410Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objective: Despite over 50 years of research on the physiological effects of sustained bed rest, data characterizing its effects on sleep macrostructure and breathing stability in humans are scarce. This study was conducted to determine the effects of continuous exposure to hypoxia and sustained best rest, both individually and combined, on nocturnal sleep and breathing stability. Methods: Eleven participants completed three randomized, counter-balanced, 21-days trials of: (1) normoxic bed rest (NBR, PIO2 = 133.1 ± 0.3), (2) hypoxic ambulatory confinement (HAMB, PIO2 = 90.0 ± 0.4) and (3) hypoxic bed rest (HBR, PIO2 = 90.0 ± 0.4; ~4,000 m equivalent altitude). Full objective polysomnography was performed at baseline, on Night 1 and Night 21 in each condition. Results: In NBR Night 1, more time was spent in light sleep (10 ± 2%) compared to baseline (8 ± 2%; p = 0.028); Slow-wave sleep (SWS) was reduced from baseline in the hypoxic-only trial by 18% (HAMB Night 21, p = 0.028) and further reduced by 33% (HBR Night 1, p = 0.010), and 36% (HBR Night 21, p = 0.008) when combined with bed rest. The apnea-hypopnea index doubled from Night 1 to Night 21 in HBR (32-62 events·h-1) and HAMB (31-59 events·h-1; p = 0.002). Those who experienced greatest breathing instability from Night 1 to Night 21 (NBR) were correlated to unchanged or higher (+1%) night SpO2 concentrations (R2 = 0.471, p = 0.020). Conclusion: Bed rest negatively affects sleep macrostructure, increases the apnea-hypopnea index, and worsens breathing stability, each independently exacerbated by continuous exposure to hypoxia.

Ort, förlag, år, upplaga, sidor
Frontiers Media S.A., 2017. Vol. 8, nr June, artikel-id 410
Nyckelord [en]
Duty ratio, High altitude, Hypoxia, Periodic breathing, Polysomnography
Nationell ämneskategori
Fysiologi
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URN: urn:nbn:se:kth:diva-210622DOI: 10.3389/fphys.2017.00410ISI: 000403718400002Scopus ID: 2-s2.0-85020910510OAI: oai:DiVA.org:kth-210622DiVA, id: diva2:1118887
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QC 20170703

Tillgänglig från: 2017-07-03 Skapad: 2017-07-03 Senast uppdaterad: 2018-01-13Bibliografiskt granskad

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