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2017 (English)In: Translational Psychiatry, E-ISSN 2158-3188, Vol. 7, article id e1177Article in journal (Refereed) Published
Abstract [en]
Immunological and inflammatory reactions have been suggested to have a role in the development of schizophrenia, a hypothesis that has recently been supported by genetic data. The aim of our study was to perform an unbiased search for autoantibodies in patients with a first psychotic episode, and to explore the association between any seroreactivity and the development of a Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) disorder characterized by chronic or relapsing psychotic symptoms. We collected plasma samples from 53 patients when they were treated for their first-episode psychosis, and 41 non-psychotic controls, after which the patients were followed for a mean duration of 7 years. Thirty patients were diagnosed with schizophrenia, delusional disorder, schizoaffective disorder, bipolar disorder or a long-term unspecified nonorganic psychosis during follow-up, whereas 23 patients achieved complete remission. At the end of follow-up, plasma samples were analyzed for IgG reactivity to 2304 fragments of human proteins using a multiplexed affinity proteomic technique. Eight patient samples showed autoreactivity to the N-terminal fragment of the PAGE (P antigen) protein family (PAGE2B/PAGE2/PAGE5), whereas no such autoreactivity was seen among the controls. PAGE autoreactivity was associated with a significantly increased risk of being diagnosed with schizophrenia during follow-up (odds ratio 6.7, relative risk 4.6). An immunohistochemistry analysis using antisera raised against the N-terminal fragment stained an unknown extracellular target in human cortical brain tissue. Our findings suggest that autoreactivity to the N-terminal portion of the PAGE protein family is associated with schizophrenia in a subset of patients with first-episode psychosis.
Place, publisher, year, edition, pages
Nature Publishing Group, 2017
National Category
Psychiatry
Identifiers
urn:nbn:se:kth:diva-212629 (URN)10.1038/tp.2017.160 (DOI)000406715200003 ()28742074 (PubMedID)2-s2.0-85046053045 (Scopus ID)
Funder
Swedish Research Council, 521-2014-3857VINNOVAKnut and Alice Wallenberg FoundationEU, FP7, Seventh Framework Programme, FP7-PEOPLE-2013-ITN-607616Science for Life Laboratory - a national resource center for high-throughput molecular bioscience
Note
QC 20170824
2017-08-242017-08-242024-03-15Bibliographically approved