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Multivalent mesoporous silica nanoparticles photo-delivering nitric oxide with carbon dots as fluorescence reporters
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2017 (English)In: Nanoscale, ISSN 2040-3364, E-ISSN 2040-3372, Vol. 9, no 36, p. 13404-13408Article in journal (Refereed) Published
Abstract [en]

Amino-terminated mesoporous silica nanoparticles embedding carbon dots (MSCD) formed by calcination were functionalized with a nitric oxide (NO) photodonor (1) to give a robust MSCD-1 conjugate. The intense fluorescence of MSCDs was strongly quenched in MSCD-1 by effective energy transfer. Visible light excitation of MSCD-1 liberates NO, suppresses the energy transfer mechanism and leads to concomitant fluorescence restoration of the MSCD scaffold, which acts as an optical reporter for the released NO. The MSCD-1 hybrid is also able to encapsulate the highly hydrophobic photosensitizer temoporfin, preserving the fluorescence reporting function.

Place, publisher, year, edition, pages
ROYAL SOC CHEMISTRY , 2017. Vol. 9, no 36, p. 13404-13408
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Chemical Sciences
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URN: urn:nbn:se:kth:diva-215811DOI: 10.1039/c7nr04832gISI: 000411613400003PubMedID: 28813066Scopus ID: 2-s2.0-85029830613OAI: oai:DiVA.org:kth-215811DiVA, id: diva2:1150190
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QC 20171018

Available from: 2017-10-18 Created: 2017-10-18 Last updated: 2024-03-18Bibliographically approved

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Feiler, Adam

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