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Removal of xenotropic murine leukemia virus by nanocellulose based filter paper
(Charles River Biopharmaceutical Services GmbH, Gottfried-Hagen Str. 20, 51105, Köln, Germany)
Charles River Biopharmaceutical Services GmbH, Gottfried-Hagen Str. 20, 51105, Köln, Germany.
Nanotechnology and Functional Materials, Department of Engineering Sciences, Box 534, Uppsala University, 75121 Uppsala, Sweden.
Nanotechnology and Functional Materials, Department of Engineering Sciences, Box 534, Uppsala University, 75121 Uppsala, Sweden.
2015 (engelsk)Inngår i: Biologicals, Vol. 43, nr 6, s. 452-456Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The removal of xenotrpic murine leukemia virus (xMuLV) by size-exclusion filter paper composed of 100% naturally derived cellulose was validated. The filter paper was produced using cellulose nanofibers derived from Cladophora sp. algae. The filter paper was characterized using atomic force microscopy, scanning electron microscopy, helium pycnometry, and model tracer (100 nm latex beads and 50 nm gold nanoparticles) retention tests. Following the filtration of xMuLV spiked solutions, LRV ≥5.25 log10 TCID50 was observed, as limited by the virus titre in the feed solution and sensitivity of the tissue infectivity test. The results of the validation study suggest that the nanocellulose filter paper is useful for removal of endogenous rodent retroviruses and retrovirus-like particles during the production of recombinant proteins.

sted, utgiver, år, opplag, sider
Elsevier, 2015. Vol. 43, nr 6, s. 452-456
HSV kategori
Identifikatorer
URN: urn:nbn:se:kth:diva-218903DOI: 10.1016/j.biologicals.2015.08.001ISI: 000365370400003Scopus ID: 2-s2.0-84946488402OAI: oai:DiVA.org:kth-218903DiVA, id: diva2:1163127
Merknad

QC 20171212

Tilgjengelig fra: 2017-12-06 Laget: 2017-12-06 Sist oppdatert: 2017-12-12bibliografisk kontrollert

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