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Multifunctional PLGA/parylene C coating for implant materials – an integral approach for biointerface optimization
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2016 (English)In: ACS Applied Materials and Interfaces, ISSN 1944-8244, E-ISSN 1944-8252, Vol. 8, p. 22093-22105Article in journal (Refereed) Published
Abstract [en]

Functionalizing implant surfaces is critical for improving their performance. An integrated approach was employedto develop a multifunctional implant coating based on oxygen plasma-modified parylene C and drug-loaded, biodegradablepoly(DL-lactide-co-glycolide) (PLGA). The key functional attributes of the coating (i.e., anti-corrosion, biocompatible, antiinfection,and therapeutic) were thoroughly characterized at each fabrication step by spectroscopic, microscopic, and biologicmethods and at different scales, ranging from molecular, through the nano- and microscales to the macroscopic scale. Thechemistry of each layer was demonstrated separately, and their mutual affinity was shown to be indispensable for thedevelopment of versatile coatings for implant applications.

Place, publisher, year, edition, pages
American Chemical Society (ACS), 2016. Vol. 8, p. 22093-22105
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Polymer Technologies
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URN: urn:nbn:se:kth:diva-224433DOI: 10.1021/acsami.6b08025ISI: 000382514100030Scopus ID: 2-s2.0-84984904303OAI: oai:DiVA.org:kth-224433DiVA, id: diva2:1191273
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QC 20180326

Available from: 2018-03-16 Created: 2018-03-16 Last updated: 2018-03-26Bibliographically approved

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Engvall, Klas

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