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Nano-graphene oxide functionalized bioactive poly(lactic acid) and poly(ε-caprolactone) nanofibrous scaffolds
KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Fiber- och polymerteknologi.
KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Fiber- och polymerteknologi, Polymerteknologi.ORCID-id: 0000-0002-7790-8987
2018 (engelsk)Inngår i: Materials, ISSN 1996-1944, E-ISSN 1996-1944, Vol. 11, nr 4, artikkel-id 566Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

A versatile and convenient way to produce bioactive poly(lactic acid) (PLA) and poly(ε-caprolactone) (PCL) electrospun nanofibrous scaffolds is described. PLA and PCL are extensively used as biocompatible scaffold materials for tissue engineering. Here, biobased nano graphene oxide dots (nGO) are incorporated in PLA or PCL electrospun scaffolds during the electrospinning process aiming to enhance the mechanical properties and endorse osteo-bioactivity. nGO was found to tightly attach to the fibers through secondary interactions. It also improved the electrospinnability and fiber quality. The prepared nanofibrous scaffolds exhibited enhanced mechanical properties, increased hydrophilicity, good cytocompatibility and osteo-bioactivity. Therefore, immense potential for bone tissue engineering applications is anticipated.

sted, utgiver, år, opplag, sider
MDPI AG , 2018. Vol. 11, nr 4, artikkel-id 566
Emneord [en]
Biomineralization, Graphene oxide, Mechanical properties, PCL, PLA, Scaffold
HSV kategori
Identifikatorer
URN: urn:nbn:se:kth:diva-227624DOI: 10.3390/ma11040566ISI: 000434710200108Scopus ID: 2-s2.0-85045050100OAI: oai:DiVA.org:kth-227624DiVA, id: diva2:1206596
Merknad

QC 20180517

Tilgjengelig fra: 2018-05-17 Laget: 2018-05-17 Sist oppdatert: 2019-11-14bibliografisk kontrollert

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Wu, DuoHakkarainen, Minna

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