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Systems biology in hepatology: approaches and applications
KTH, Centra, Science for Life Laboratory, SciLifeLab. Chalmers Univ Technol, Dept Biol & Biol Engn, Gothenburg, Sweden..ORCID-id: 0000-0002-4254-6090
Univ Gothenburg, Dept Mol & Clin Med, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Gothenburg, Sweden..ORCID-id: 0000-0003-0786-8091
Univ Gothenburg, Dept Mol & Clin Med, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Gothenburg, Sweden..ORCID-id: 0000-0002-1439-4608
KTH, Centra, Science for Life Laboratory, SciLifeLab.ORCID-id: 0000-0002-4858-8056
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2018 (Engelska)Ingår i: Nature Reviews. Gastroenterology & Hepatology, ISSN 1759-5045, E-ISSN 1759-5053, Vol. 15, nr 6, s. 365-377Artikel, forskningsöversikt (Refereegranskat) Published
Abstract [en]

Detailed insights into the biological functions of the liver and an understanding of its crosstalk with other human tissues and the gut microbiota can be used to develop novel strategies for the prevention and treatment of liver-associated diseases, including fatty liver disease, cirrhosis, hepatocellular carcinoma and type 2 diabetes mellitus. Biological network models, including metabolic, transcriptional regulatory, protein-protein interaction, signalling and co-expression networks, can provide a scaffold for studying the biological pathways operating in the liver in connection with disease development in a systematic manner. Here, we review studies in which biological network models were used to integrate multiomics data to advance our understanding of the pathophysiological responses of complex liver diseases. We also discuss how this mechanistic approach can contribute to the discovery of potential biomarkers and novel drug targets, which might lead to the design of targeted and improved treatment strategies. Finally, we present a roadmap for the successful integration of models of the liver and other human tissues with the gut microbiota to simulate whole-body metabolic functions in health and disease.

Ort, förlag, år, upplaga, sidor
Nature Publishing Group, 2018. Vol. 15, nr 6, s. 365-377
Nationell ämneskategori
Gastroenterologi
Identifikatorer
URN: urn:nbn:se:kth:diva-230482DOI: 10.1038/s41575-018-0007-8ISI: 000433166800010PubMedID: 29686404Scopus ID: 2-s2.0-85045834478OAI: oai:DiVA.org:kth-230482DiVA, id: diva2:1217741
Forskningsfinansiär
Knut och Alice Wallenbergs StiftelseScience for Life Laboratory - a national resource center for high-throughput molecular bioscience
Anmärkning

QC 20180613

Tillgänglig från: 2018-06-13 Skapad: 2018-06-13 Senast uppdaterad: 2020-01-10Bibliografiskt granskad

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Mardinoglu, AdilUhlén, MathiasNielsen, Jens

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Mardinoglu, AdilBoren, JanSmith, UlfUhlén, MathiasNielsen, Jens
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Science for Life Laboratory, SciLifeLab
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Nature Reviews. Gastroenterology & Hepatology
Gastroenterologi

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