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Cathepsins: Proteases that are vital for survival but can also be fatal
San Diego State Univ, Bioinformat & Med Informat Res Ctr, 5500 Campanile Dr, San Diego, CA 92182 USA..
Univ Hormozgan, Fac Marine Sci & Technol, Dept Marine Biol, Bandar Abbas, Iran.;Univ Hormozgan, Dept Biol, Fac Sci, Bandar Abbas, Iran..
Uppsala Univ, Biomed Ctr, Dept Med Chem, Div Pharmacognosy, Box 574, SE-75123 Uppsala, Sweden.
Univ Guelph, Dept Anim Biosci, Guelph, ON N1G 2W1, Canada..ORCID-id: 0000-0002-0574-1102
2018 (Engelska)Ingår i: Biomedicine and Pharmacotherapy, ISSN 0753-3322, E-ISSN 1950-6007, Vol. 105, s. 526-532Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The state of enzymes in the human body determines the normal physiology or pathology, so all the six classes of enzymes are crucial. Proteases, the hydrolases, can be of several types based on the nucleophilic amino acid or the metal cofactor needed for their activity. Cathepsins are proteases with serine, cysteine, or aspartic acid residues as the nucleophiles, which are vital for digestion, coagulation, immune response, adipogenesis, hormone liberation, peptide synthesis, among a litany of other functions. But inflammatory state radically affects their normal roles. Released from the lysosomes, they degrade extracellular matrix proteins such as collagen and elastin, mediating parasite infection, autoimmune diseases, tumor metastasis, cardiovascular issues, and neural degeneration, among other health hazards. Over the years, the different types and isoforms of cathepsin, their optimal pH and functions have been studied, yet much information is still elusive. By taming and harnessing cathepsins, by inhibitors and judicious lifestyle, a gamut of malignancies can be resolved. This review discusses these aspects, which can be of clinical relevance.

Ort, förlag, år, upplaga, sidor
Elsevier, 2018. Vol. 105, s. 526-532
Nyckelord [en]
Cathepsin, Immune activation, Inflammation, Extracellular matrix, Carcinogenesis, Inhibitors
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
URN: urn:nbn:se:kth:diva-233410DOI: 10.1016/j.biopha.2018.05.148ISI: 000438312600058PubMedID: 29885636Scopus ID: 2-s2.0-85047992869OAI: oai:DiVA.org:kth-233410DiVA, id: diva2:1240408
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QC 20180821

Tillgänglig från: 2018-08-21 Skapad: 2018-08-21 Senast uppdaterad: 2018-08-21Bibliografiskt granskad

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El-Seedi, Hesham R.

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