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Quantifying Size Exclusion by Diffusion NMR: A Versatile Method to Measure Pore Access and Pore Size
KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Tillämpad fysikalisk kemi. GE Healthcare Biosci AB, Bjorkgatan 31, SE-75184 Uppsala, Sweden..
GE Healthcare Biosci AB, Bjorkgatan 31, SE-75184 Uppsala, Sweden..
KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Tillämpad fysikalisk kemi. GE Healthcare Biosci AB, Bjorkgatan 31, SE-75184 Uppsala, Sweden..ORCID-id: 0000-0002-0231-3970
2018 (Engelska)Ingår i: Analytical Chemistry, ISSN 0003-2700, E-ISSN 1520-6882, Vol. 90, nr 19, s. 11431-11438Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Size-exclusion quantification NMR spectroscopy (SEQNMR) is introduced for measuring equilibrium distribution coefficients, K-eq, in porous media. The porous medium is equilibrated with a polydisperse polymer solution. The original bulk polymer solution and the polymer solution after equilibration but in the absence of the porous medium are analyzed by NMR diffusion experiments. The joint evaluation of the two diffusion attenuation curves under suitable constraints provides the extent by which polymer fractions of particular size were depleted from the solution by pore access. This procedure yields K-eq versus polymer probe size, the selectivity curve that in turn can provide the pore size and its distribution. Simulations probe the performance of the method that is demonstrated experimentally in chromatographic media using dextran polymers. SEQ-NMR and inverse size- exclusion chromatography (ISEC) yield selectivity curves that virtually coincide. Crucial advantages with SEQ-NMR, such as versatility with regard to both the polymer used and porous system explored, high speed, potential for automation, and small required sample volume, are discussed.

Ort, förlag, år, upplaga, sidor
American Chemical Society (ACS), 2018. Vol. 90, nr 19, s. 11431-11438
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Fysikalisk kemi
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URN: urn:nbn:se:kth:diva-237102DOI: 10.1021/acs.analchem.8b02474ISI: 000446542600038PubMedID: 30148342Scopus ID: 2-s2.0-85053359929OAI: oai:DiVA.org:kth-237102DiVA, id: diva2:1259501
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QC 20181030

Tillgänglig från: 2018-10-30 Skapad: 2018-10-30 Senast uppdaterad: 2018-10-30Bibliografiskt granskad

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