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Lab-on-DVD: Optical Disk Drive-Based Platforms for Point-of-Care Diagnostics
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Protein Science, Nano Biotechnology.ORCID iD: 0000-0001-9869-7181
KTH, Centres, Science for Life Laboratory, SciLifeLab. KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Protein Science, Nano Biotechnology.ORCID iD: 0000-0002-0242-358X
2018 (English)In: Frugal Innovation in Bioengineering for the Detection of Infectious Diseases / [ed] AK Chavali, R Ramji, Switzerland: Springer, 2018, 2, p. 23-38Chapter in book (Refereed)
Abstract [en]

There is a growing demand for simple, affordable, reliable and quality-assured point-of-care (POC) diagnostics for use in resource-limited settings. Among the top ten leading causes of death worldwide, three are infectious diseases, namely, respiratory infections, HIV/AIDS and diarrheal diseases (World Health Organization 2012). Although high-quality diagnostic tests are available, these are often not available to patients in developing countries. While recent development in microfluidics and “lab-on-a-chip” devices has the potential to spur the development of protocols and affordable instruments for diagnosis of infectious disease at POC, integration of complex sample preparation and detection into automated molecular and cellular systems remain a bottleneck for implementation of these systems at resource-limited settings. Towards this, we describe here how low-cost optical drives can, with minor modifications, be turned into POC diagnostic platforms. A DVD drive is essentially a highly advanced and low-cost optical laser-scanning microscope, with the capability to deliver high-resolution images for biological applications. Furthermore, the inherent centrifugal force on rotational discs is elegantly used for sample preparation and integration. Hence, the merging of low-cost optical disc drives with centrifugal microfluidics is feasible concept for POC diagnostics, specifically designed to meet the needs at resource-limited settings.

Place, publisher, year, edition, pages
Switzerland: Springer, 2018, 2. p. 23-38
Keywords [en]
Lab on DVD
National Category
Medical Biotechnology
Research subject
Biotechnology
Identifiers
URN: urn:nbn:se:kth:diva-238686DOI: 10.1007/978-3-319-66647-1_2Scopus ID: 2-s2.0-85046595193ISBN: 978-3-319-66647-1 (electronic)OAI: oai:DiVA.org:kth-238686DiVA, id: diva2:1261574
Note

QC 20181112

Available from: 2018-11-07 Created: 2018-11-07 Last updated: 2018-11-12Bibliographically approved

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Publisher's full textScopushttps://link-springer-com.focus.lib.kth.se/content/pdf/10.1007/978-3-319-66647-1.pdf

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Russom, Aman

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