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Regulation of sex hormone receptors in sexual dimorphism of human cancers
Dept Canc Biol, 4500 San Pablo Rd, Jacksonville, FL 32224 USA..
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Protein Science, Cellular and Clinical Proteomics. KTH, Centres, Science for Life Laboratory, SciLifeLab. Karolinska Institute.ORCID iD: 0000-0002-0602-2062
Mayo Canc Registry, 4500 San Pablo Rd, Jacksonville, FL 32224 USA..
Mayo Clin, Dept Surg, 4500 San Pablo Rd, Jacksonville, FL 32224 USA.;Mayo Clin, Mayo Clin Canc Ctr, 4500 San Pablo Rd, Jacksonville, FL 32224 USA..
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2018 (English)In: Cancer Letters, ISSN 0304-3835, E-ISSN 1872-7980, Vol. 438, p. 24-31Article, review/survey (Refereed) Published
Abstract [en]

Gender differences in the incidences of cancers have been found in almost all human cancers. However, the mechanisms that underlie gender disparities in most human cancer types have been under-investigated. Here, we provide a comprehensive overview of potential mechanisms underlying sexual dimorphism of each cancer regarding sex hormone signaling. Fully addressing the mechanisms of sexual dimorphism in human cancers will greatly benefit current development of precision medicine. Our discussions of potential mechanisms underlying sexual dimorphism in each cancer will be instructive for future cancer research on gender disparities.

Place, publisher, year, edition, pages
Elsevier, 2018. Vol. 438, p. 24-31
Keywords [en]
Sexual dimorphism, Cancer incidence, Sex hormones, Estrogen receptor, Androgen receptor
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:kth:diva-239513DOI: 10.1016/j.canlet.2018.09.001ISI: 000449139400004PubMedID: 30223066Scopus ID: 2-s2.0-85053435783OAI: oai:DiVA.org:kth-239513DiVA, id: diva2:1265916
Funder
Swedish Cancer SocietySwedish Research Council
Note

QC 20181126

Available from: 2018-11-26 Created: 2018-11-26 Last updated: 2018-11-26Bibliographically approved

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CiteExportLink to record
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  • apa
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