Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Porous Cellulose Nanofiber-Based Microcapsules for Biomolecular Sensing
KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Fiber- och polymerteknologi.
KTH, Skolan för teknikvetenskap (SCI), Tillämpad fysik, Experimentell biomolekylär fysik. KTH, Centra, Science for Life Laboratory, SciLifeLab. ..ORCID-id: 0000-0002-1850-5440
KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Fiber- och polymerteknologi.
KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Fiber- och polymerteknologi.ORCID-id: 0000-0002-7674-0262
Visa övriga samt affilieringar
2018 (Engelska)Ingår i: ACS Applied Materials and Interfaces, ISSN 1944-8244, E-ISSN 1944-8252, Vol. 10, nr 48, s. 41146-41154Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Cellulose nanofibers (CNFs) have recently attracted a lot of attention in sensing because of their multifunctional character and properties such as renewability, nontoxicity, biodegradability, printability, and optical transparency in addition to unique physicochemical, barrier, and mechanical properties. However, the focus has exclusively been devoted toward developing two-dimensional sensing platforms in the form of nanopaper or nanocellulose-based hydrogels. To improve the flexibility and sensing performance in situ, for example, to detect biomarkers in vivo for early disease diagnostics, more advanced CNF-based structures are needed. Here, we developed porous and hollow, yet robust, CNF-based microcapsules using only the primary plant cell wall components, CNF, pectin, and xyloglucan, to assemble the capsule wall. The fluorescein isothiocyanate-labeled dextrans with M-w of 70 and 2000 kDa could enter the hollow capsules at a rate of 0.13 +/- 0.04 and 0.014 +/- 0.009 s(-1), respectively. This property is very attractive because it minimizes the influence of mass transport through the capsule wall on the response time. As a proof of concept, glucose oxidase (GOx) enzyme was loaded (and cross-linked) in the microcapsule interior with an encapsulation efficiency of 68 +/- 2%. The GOx-loaded microcapsules were immobilized on a variety of surfaces (here, inside a flow channel, on a carbon-coated sensor or a graphite rod) and glucose concentrations up to 10 mM could successfully be measured. The present concept offers new opportunities in the development of simple, more efficient, and disposable nanocellulose-based analytical devices for several sensing applications including environmental monitoring, healthcare, and diagnostics.

Ort, förlag, år, upplaga, sidor
American Chemical Society (ACS), 2018. Vol. 10, nr 48, s. 41146-41154
Nyckelord [en]
cellulose nanofibers, microcapsules, glucose oxidase, sensing, sensor, layer-by-layer
Nationell ämneskategori
Polymerteknologi
Identifikatorer
URN: urn:nbn:se:kth:diva-240733DOI: 10.1021/acsami.8b16058ISI: 000452694100022PubMedID: 30412378Scopus ID: 2-s2.0-85057799223OAI: oai:DiVA.org:kth-240733DiVA, id: diva2:1277062
Forskningsfinansiär
Stiftelsen för strategisk forskning (SSF), ICA14-0045Vetenskapsrådet, VR-2017-4887Science for Life Laboratory - a national resource center for high-throughput molecular bioscience
Anmärkning

QC 20190109

Tillgänglig från: 2019-01-09 Skapad: 2019-01-09 Senast uppdaterad: 2019-01-09Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltextPubMedScopus

Personposter BETA

Wennmalm, StefanWu, QiongCrespo, Gaston A.

Sök vidare i DiVA

Av författaren/redaktören
Paulraj, ThomasWennmalm, StefanRiazanova, Anastasia, VWu, QiongCrespo, Gaston A.Svagan, Anna J.
Av organisationen
Fiber- och polymerteknologiExperimentell biomolekylär fysikScience for Life Laboratory, SciLifeLabTillämpad fysikalisk kemi
I samma tidskrift
ACS Applied Materials and Interfaces
Polymerteknologi

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 134 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf