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A micro-dispenser for long-term storage and controlled release of liquids
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Protein Science, Nano Biotechnology. KTH, Centres, Science for Life Laboratory, SciLifeLab.
KTH, School of Engineering Sciences (SCI), Mechanics.ORCID iD: 0000-0002-5819-4544
Univ Calif Irvine, Dept Mech & Aerosp Engn, Irvine, CA 92697 USA..
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Protein Science, Nano Biotechnology. KTH, Centres, Science for Life Laboratory, SciLifeLab.ORCID iD: 0000-0002-0242-358X
2019 (English)In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 10, no 1, article id 189Article in journal (Refereed) Published
Abstract [en]

The success of lab-on-a-chip systems may depend on a low-cost device that incorporates on-chip storage and fluidic operations. To date many different methods have been developed that cope separately with on-chip storage and fluidic operations e. g., hydrophobic and capillary valves pneumatic pumping and blister storage packages. The blister packages seem difficult to miniaturize and none of the existing liquid handling techniques despite their variety are capable of proportional repeatable dispensing. We report here on an inexpensive robust and scalable micro-dispenser that incorporates long-term storage and aliquoting of reagents on different microfluidics platforms. It provides long-term shelf-life for different liquids enables precise dispensing on lab-on-a-disc platforms and less accurate but proportional dispensing when operated by finger pressure. Based on this technology we introduce a method for automation of blood plasma separation and multi-step bioassay procedures. This micro-dispenser intends to facilitate affordable portable diagnostic devices and accelerate the commercialization of lab-on-a-chip devices.

Place, publisher, year, edition, pages
Nature Publishing Group, 2019. Vol. 10, no 1, article id 189
National Category
Other Electrical Engineering, Electronic Engineering, Information Engineering
Identifiers
URN: urn:nbn:se:kth:diva-242976DOI: 10.1038/s41467-018-08091-zISI: 000455595400012PubMedID: 30643146Scopus ID: 2-s2.0-85060061742OAI: oai:DiVA.org:kth-242976DiVA, id: diva2:1284845
Funder
Science for Life Laboratory - a national resource center for high-throughput molecular bioscience
Note

QC 20190201

Available from: 2019-02-01 Created: 2019-02-01 Last updated: 2019-02-01Bibliographically approved

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Kazemzadeh, AminEriksson, AndersRussom, Aman

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