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Surface functionalization of polylactic acid fibers with alendronate groups does not improve the mechanical properties of fiber-reinforced calcium phosphate cements
Radboud Univ Nijmegen, Med Ctr, Dept Regenerat Biomat, Philips Leydenlaan 25, NL-6525 EX Nijmegen, Netherlands..
Radboud Univ Nijmegen, Med Ctr, Dept Regenerat Biomat, Philips Leydenlaan 25, NL-6525 EX Nijmegen, Netherlands.;CAM Bioceram BV, Zernikedreef 6, NL-2333 CL Leiden, Netherlands..
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology. Univ Utrecht, Fac Sci, UIPS, Dept Pharmaceut, NL-3508 TB Utrecht, Netherlands..
Univ Utrecht, Fac Sci, UIPS, Dept Pharmaceut, NL-3508 TB Utrecht, Netherlands..
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2019 (English)In: Journal of The Mechanical Behavior of Biomedical Materials, ISSN 1751-6161, E-ISSN 1878-0180, Vol. 90, p. 472-483Article in journal (Refereed) Published
Abstract [en]

Calcium phosphate cements (CPCs) are frequently used as synthetic bone substitute, but their intrinsic low fracture toughness impedes their application in highly loaded skeletal sites. However, fibers can be used to reduce the brittleness of these CPCs provided that the affinity between the fibers and cement matrix facilitates the transfer of loads from the matrix to the fibers. The aim of the present work was to improve the interface between hydrophobic polylactic acid (PLA) microfibers and hydrophilic CPC. To this end, calcium-binding alendronate groups were conjugated onto the surface of PLA microfibers via different strategies to immobilize a tunable amount of alendronate onto the fiber surface. CPCs reinforced with PLA fibers revealed toughness values which were up to 50-fold higher than unreinforced CPCs. Nevertheless, surface functionalization of PLA microfibers with alendronate groups did not improve the mechanical properties of fiber-reinforced CPCs.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE BV , 2019. Vol. 90, p. 472-483
Keywords [en]
Calcium phosphate cements, Reinforcement, Polyester, Affinity, Alendronate
National Category
Medical Biotechnology
Identifiers
URN: urn:nbn:se:kth:diva-244108DOI: 10.1016/j.jmbbm.2018.11.003ISI: 000457510500052PubMedID: 30448561Scopus ID: 2-s2.0-85056481582OAI: oai:DiVA.org:kth-244108DiVA, id: diva2:1289790
Note

QC 20190219

Available from: 2019-02-19 Created: 2019-02-19 Last updated: 2019-02-19Bibliographically approved

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Abbadessa, Anna

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