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Overview of Alternative Separation Methods in Relation to Process Challenges
KTH.
2018 (English)In: Biopharmaceutical Processing: Development, Design, and Implementation of Manufacturing Processes, Elsevier , 2018, p. 207-220Chapter in book (Other academic)
Abstract [en]

This chapter provides an overview of alternative separation methods in order to help the reader decide if such methods are of interest, how they compare with other methods, and what particular approaches may suit specific process challenges. Alternative separation methods are enjoying a resurgence of interest for use in bioprocessing as they have the ability to handle various challenges that tax the limits of industry "workhorse" methods such as centrifugation, filtration, and chromatography. They are proven, readily scaled, and do not require significant energy input or capital investment. Although they typically involve a single separation stage, alternative separation methods can still offer effective separations. They are well-suited to be used in the initial stages of bioprocessing, either in target-capture or contaminant-removal modes. In addition, they are compatible with modern high-throughput screening of operating conditions, as well as single-use equipment for batch or continuous processing. This chapter presents a survey of a wide range of alternative separation methods and key references. The next two chapters provide more details, including some cost of goods estimation references, in regard to the popular methods of flocculation and precipitation (Chapter 11) as well as two methods of growing interest; crystallization, and liquid-liquid aqueous polymer two-phase extraction (Chapter 12).

Place, publisher, year, edition, pages
Elsevier , 2018. p. 207-220
Keywords [en]
Alternative separation, Bioprocess, Clarification, Crystallization, Extraction, Partition, Precipitation, Purification and separation
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:kth:diva-247227DOI: 10.1016/B978-0-08-100623-8.00010-4Scopus ID: 2-s2.0-85054380145ISBN: 9780128125526 (print)ISBN: 9780081006238 (print)OAI: oai:DiVA.org:kth-247227DiVA, id: diva2:1301644
Note

QC 20190402

Available from: 2019-04-02 Created: 2019-04-02 Last updated: 2019-04-02Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
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  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf