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An ingestible self-orienting system for oral delivery of macromolecules
MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA..
MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA.;MIT, Inst Med Engn & Sci, 77 Massachusetts Ave, Cambridge, MA 02139 USA..ORCID iD: 0000-0002-2844-7598
MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA..
MIT, Inst Med Engn & Sci, 77 Massachusetts Ave, Cambridge, MA 02139 USA..
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2019 (English)In: Science, ISSN 0036-8075, E-ISSN 1095-9203, Vol. 363, no 6427, p. 611-+Article in journal (Refereed) Published
Abstract [en]

Biomacromolecules have transformed our capacity to effectively treat diseases; however, their rapid degradation and poor absorption in the gastrointestinal (GI) tract generally limit their administration to parenteral routes. An oral biologic delivery system must aid in both localization and permeation to achieve systemic drug uptake. Inspired by the leopard tortoise's ability to passively reorient, we developed an ingestible self-orienting millimeter-scale applicator (SOMA) that autonomously positions itself to engage with GI tissue. It then deploys milliposts fabricated from active pharmaceutical ingredients directly through the gastric mucosa while avoiding perforation. We conducted in vivo studies in rats and swine that support the applicator's safety and, using insulin as a model drug, demonstrated that the SOMA delivers active pharmaceutical ingredient plasma levels comparable to those achieved with subcutaneous millipost administration.

Place, publisher, year, edition, pages
AMER ASSOC ADVANCEMENT SCIENCE , 2019. Vol. 363, no 6427, p. 611-+
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Pharmaceutical Sciences
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URN: urn:nbn:se:kth:diva-244513DOI: 10.1126/science.aau2277ISI: 000458114200044PubMedID: 30733413Scopus ID: 2-s2.0-85061192140OAI: oai:DiVA.org:kth-244513DiVA, id: diva2:1301729
Note

QC 20190402

Available from: 2019-04-02 Created: 2019-04-02 Last updated: 2019-04-04Bibliographically approved

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