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Biocompatibility of Resorbable Polymers: A Historical Perspective and Framework for the Future
Univ Sannio, Dept Sci & Technol, Via Mulini, I-82100 Benevento, Italy..
Novus Sci AB, Virdings Alle 2, S-75450 Uppsala, Sweden..
KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Fiber- och polymerteknologi.ORCID-id: 0000-0002-1922-128X
2019 (Engelska)Ingår i: Biomacromolecules, ISSN 1525-7797, E-ISSN 1526-4602, Vol. 20, nr 4, s. 1465-1477Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The history of resorbable polymers containing glycolide, lactide, e-caprolactone and trimethylene carbonate, with a special emphasis being placed on the time frame of the 1960s-1990s is described. Reviewing the history is valuable when looking into the future perspectives regarding how and where these monomers should be used. This story includes scientific evaluations indicating that these polymers are safe to use in medical devices, while the design of the medical device is not considered in this report. In particular, we present the data regarding the tissue response to implanted polymers, as well as the toxicity and pharmacokinetics of their degradation products. In the translation of these polymers from "the bench to the bedside," various challenges have been faced by surgeons, medical doctors, biologists, material engineers and polymer chemists. This Perspective highlights the visionary role played by the pioneers, addressing the problems that occurred on a case by case basis in translational medicine.

Ort, förlag, år, upplaga, sidor
AMER CHEMICAL SOC , 2019. Vol. 20, nr 4, s. 1465-1477
Nyckelord [en]
NDUNNEN WFA, 1993, JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, V4, P521 nmark S., 2011, ACTA BIOMATERIALIA, V7, P2035 go AP, 2003, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, V67A, P1044, NDUNNEN WFA, 1993, MICROSURGERY, V14, P508 go AP, 2002, MACROMOLECULAR BIOSCIENCE, V2, P411, NDUNNEN WFA, 1995, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, V29, P757, LGUERRA RS, 1994, JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, V5, P891 e of International Standard., 2016, ISO 109931, ndgren D., 1994, J. Swed. Dent. Assoc, V65, P967
Nationell ämneskategori
Polymerkemi
Identifikatorer
URN: urn:nbn:se:kth:diva-251216DOI: 10.1021/acs.biomac.9b00159ISI: 000464248300001PubMedID: 30855137Scopus ID: 2-s2.0-85064110982OAI: oai:DiVA.org:kth-251216DiVA, id: diva2:1317918
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QC 20190524

Tillgänglig från: 2019-05-24 Skapad: 2019-05-24 Senast uppdaterad: 2019-05-24Bibliografiskt granskad

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Finne Wistrand, Anna

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