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Carbon dioxide-catalyzed peroxynitrite reactivity - The resilience of the radical mechanism after two decades of research
Univ Sao Paulo, Inst Quim, Dept Bioquim, BR-5508000 Sao Paulo, Brazil..
Hebrew Univ Jerusalem, Chem Inst, IL-91904 Jerusalem, Israel..
Oregon State Univ, Dept Biochem & Biophys, Corvallis, OR 97331 USA..
KTH, Skolan för kemi, bioteknologi och hälsa (CBH).
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2019 (engelsk)Inngår i: Free Radical Biology & Medicine, ISSN 0891-5849, Vol. 135, s. 210-215Artikkel, forskningsoversikt (Fagfellevurdert) Published
Abstract [en]

Peroxynitrite, ONOO-, formed in tissues that are simultaneously generating NO center dot and O-2(center dot-), is widely regarded as a major contributor to oxidative stress. Many of the reactions involved are catalyzed by CO2 via formation of an unstable adduct, ONOOC(O)O-, that undergoes O-O bond homolysis to produce NO2 center dot and CO3 center dot- radicals, whose yields are equal at about 0.33 with respect to the ONOO- reactant. Since its inception two decades ago, this radical-based mechanism has been frequently but unsuccessfully challenged. The most recent among these [Serrano-Luginbuehl et al. Chem. Res. Toxicol. 31: 721-730; 2018] claims that ONOOC(O)O- is stable, predicts a yield of NO2 center dot/CO3 center dot- of less than 0.01 under physiological conditions and, contrary to widely accepted viewpoints, suggests that radical generation is inconsequential to peroxynitrite-induced oxidative damage. Here we review the experimental and theoretical evidence that support the radical model and show this recently proposed alternative mechanism to be incorrect.

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ELSEVIER SCIENCE INC , 2019. Vol. 135, s. 210-215
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URN: urn:nbn:se:kth:diva-252395DOI: 10.1016/j.freeradbiomed.2019.02.026ISI: 000465927200020PubMedID: 30818056Scopus ID: 2-s2.0-85063040223OAI: oai:DiVA.org:kth-252395DiVA, id: diva2:1324159
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QC 20190613

Tilgjengelig fra: 2019-06-13 Laget: 2019-06-13 Sist oppdatert: 2019-06-13bibliografisk kontrollert

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