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Silica and carbon decorated silica nanosheet impact on primary human immune cells
KTH, School of Engineering Sciences (SCI), Applied Physics.
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2018 (English)In: Colloids and Surfaces B: Biointerfaces, ISSN 0927-7765, E-ISSN 1873-4367, Vol. 172, p. 779-789Article in journal (Refereed) Published
Abstract [en]

Silica nanosheets (SiO 2 NS) are considered to be a promising material in clinical practice for diagnosis and therapy applications. However, an appropriate surface functionalization is essential to guarantee high biocompatibility and molecule loading ability. Although SiO 2 NS are chemically stable, its effects on immune systems are still being explored. In this work, we successfully synthesized a novel 2D multilayer SiO 2 NS and SiO 2 NS coated with carbon (C/SiO 2 NS), and evaluated their impact on human Peripheral Blood Mononuclear Cells (PBMCs) and some immune cell subpopulations. We demonstrated that the immune response is strongly dependent on the surface functionalities of the SiO 2 NS. Ex vivo experiments showed an increase in biocompatibility of C/SiO 2 NS compared to SiO 2 NS, resulting in a lowering of hemoglobin release together with a reduction in cellular toxicity and cellular activation. However, none of them are directly involved in the activation of the acute inflammation process with a consequent release of pro-inflammatory cytokines. The obtained results provide an important direction towards the biomedical applications of silica nanosheets, rendering them an attractive material for the development of future immunological therapies.

Place, publisher, year, edition, pages
Elsevier B.V. , 2018. Vol. 172, p. 779-789
Keywords [en]
2D materials, Apoptosis assay, Bio compatibility, Carbon coated SiO 2, Cell toxicity, Cell viability, Characterization, Hemolysis tests, Immune cell, Layered silica, Nano-sheets, Secretion assay, Silica, Synthesis, Tumor necrosis factor alpha (TNFα), Biocompatibility, Carbon, Cell death, Chemical activation, Coated materials, Diagnosis, Immune system, Medical applications, Nanosheets, Synthesis (chemical), Toxicity, Apoptosis assays, Carbon-coated, Hemolysis test, Immune cells, Tumor necrosis factor alpha, carbon coated silica nanosheet, cytokine, hemoglobin, mulitlayer silica nanosheet, nanosheet, tumor necrosis factor, unclassified drug, adult, Article, cell activation, cell subpopulation, coated particle, controlled study, cytotoxicity, ex vivo study, hemoglobin synthesis, hemolysis assay, human, human cell, immune response, immunocompetent cell, inflammation, material coating, peripheral blood mononuclear cell, porosity, priority journal, protein secretion, structure analysis, surface area, surface property
National Category
Medical Biotechnology
Identifiers
URN: urn:nbn:se:kth:diva-247029DOI: 10.1016/j.colsurfb.2018.09.022ISI: 000455858500092Scopus ID: 2-s2.0-85053867225OAI: oai:DiVA.org:kth-247029DiVA, id: diva2:1330723
Note

QC 20190626

Available from: 2019-06-26 Created: 2019-06-26 Last updated: 2019-06-26Bibliographically approved

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Al-Soubaihi, RolaDutta, Joydeep

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