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Novel sample-substrates for the determination of new psychoactive substances in oral fluid by desorption electrospray ionization-high resolution mass spectrometry
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology, Polymer Technology.
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2019 (English)In: Talanta: The International Journal of Pure and Applied Analytical Chemistry, ISSN 0039-9140, E-ISSN 1873-3573, Vol. 202, p. 136-144Article in journal (Refereed) Published
Abstract [en]

A reliable screening and non invasive method based on the use of microextraction by packed sorbent coupled with desorption electrospray ionization-high resolution mass spectrometry was developed and validated for the detection of new psychoactive substances in oral fluid. The role of different sample substrates in enhancing signal intensity and stability was evaluated by testing the performances of two polylactide-based materials, i.e. non-functionalized and functionalized with carbon nanoparticles, and a silica-based material compared to commercially available polytetrafluorethylene supports. The best results were achieved by using the non-functionalized polylactide substrates to efficiently ionize compounds in positive ionization mode, whereas the silica coating proved to be the best choice for operating in negative ionization mode. LLOQs in the low μg/L, a good precision with CV% always lower than 16% and RR% in the 83(±4)-120(±2)% range, proved the suitability of the developed method for the determination of the analytes in oral fluid. Finally, the method was applied for screening oral fluid samples for the presence of psychoactive substances during private parties, revealing mephedrone in only one sample out of 40 submitted to analysis.

Place, publisher, year, edition, pages
Elsevier B.V. , 2019. Vol. 202, p. 136-144
Keywords [en]
Desorption electrospray ionization, High resolution mass spectrometry, New psychoactive substances, Sample-substrates, Desorption, Mass spectrometry, Noninvasive medical procedures, Polyesters, Screening, Silica, Carbon Nano-Particles, Micro-extraction by packed sorbents, Noninvasive methods, Polytetrafluorethylene, Silica based materials, Electrospray ionization
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Polymer Chemistry
Identifiers
URN: urn:nbn:se:kth:diva-252452DOI: 10.1016/j.talanta.2019.04.057ISI: 000472693700015Scopus ID: 2-s2.0-85064881748OAI: oai:DiVA.org:kth-252452DiVA, id: diva2:1337469
Note

QC 20190715

Available from: 2019-07-15 Created: 2019-07-15 Last updated: 2019-07-29Bibliographically approved

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Benyahia Erdal, NejlaHakkarainen, Minna

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Polymer TechnologyFibre- and Polymer Technology
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