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Particle focusing dynamics in extended elasto inertial flow
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Protein Science, Nano Biotechnology.ORCID iD: 0000-0001-9869-7181
KTH, School of Engineering Sciences (SCI), Mechanics.ORCID iD: 0000-0002-9004-2292
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Protein Science, Nano Biotechnology.ORCID iD: 0000-0003-0956-2002
KTH, School of Engineering Sciences (SCI), Mechanics.ORCID iD: 0000-0002-4346-4732
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2018 (English)Conference paper, Poster (with or without abstract) (Refereed)
Abstract [en]

Elasto Inertial microfluidics has been exploited recently for a number of industrial and biological applications. Recently, we experimentally showed that it is possible to achieve single stream focusing of particles even at higher flow rates in the elasto inertial regime, relevant to flow cytometry applications, and , based on this concept, built a silica fibre based micro flow cytometer.1 However, the physics behind the focusing of particles is still poorly understood, specially for combinations of higher Reynolds (Re) and Weissenberg numbers(Wi).

In the present study, for the first time, we seek to understand both experimentally and with numerical simulations, particle focusing across elasticity regimes. We vary the concentration of PEO (200 ppm to upto 10000 ppm) in PBS solution at sufficiently high flow rates of 100!l/min or above. We introduce a parameter, focusing bandwidth (F) to evaluate the extent of single stream focusing of 15 !m particles in a 75 !m diameter circular channel. Fig.1 shows the flow setup(fig.1a) along with images demonstrating the focused (fig.1b) and unfocused cases(fig.1c), as well as how F is calculated(fig.1d). We evaluate particle focusing by identifying the flow conditions for each concentration that leads to the minimum value of F. Fig.2 shows the variation of the focusing bandwidth(fig.2a) when changing PEO concentration, and the variation in Re along with Wi (fig.2b) and Elasticity number(El). The results show that for identical mass flow conditions across the different regimes the focusing bandwidth slowly shifts to a narrow single stream with increasing elasticity. We validated our experimental results as well as gained new insights into particle focusing with 3D numerical simulations based on a FENE P model. We studied the decoupled effects of Reynolds number and Weissenberg number on particle focusing, as well as the particle trajectories and migration dynamics as the particles reach equilibrium. Interestingly, enough we find a combination of high Re(Re=400) and sufficiently high Wi(Wi=3) for which the particles achieve a single stream focusing (fig.3a). The entire dynamics of particle migration in a circular cross section is also shown (in fig.3b) by changing Wi for a constant Re(Re=200). It can be seen that the particle goes through a longer amount of oscillations to reach its final equilibrium position as Wi is increased. Fig.4a shows the equilibrium position of the particle moving closer to the center with an increase in Wi at the same Re(Re=200). However, in the Non Newtonian cases, the particle has a slight oscillatory behaviour as it reaches its equilibrium position as compared to the Newtonian one. We introduced the particle at two different positions(at Re=200, We=0 and 1) and observed the same equilibrium positions in both cases (Fig.4b).

Place, publisher, year, edition, pages
2018.
National Category
Engineering and Technology
Research subject
Engineering Mechanics; Biotechnology
Identifiers
URN: urn:nbn:se:kth:diva-255645OAI: oai:DiVA.org:kth-255645DiVA, id: diva2:1340304
Conference
Twenty Second International Conference on Miniaturized Systems for Chemistry and Life Sciences
Note

QC 20190902

Available from: 2019-08-05 Created: 2019-08-05 Last updated: 2019-09-02Bibliographically approved

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Banerjee, IndradumnaRosti, Marco E.Kumar, TharaganBrandt, LucaRussom, Aman

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